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- W2914098003 endingPage "534" @default.
- W2914098003 startingPage "505" @default.
- W2914098003 abstract "Abnormal blood and lymphatic vessels create a hostile tumor microenvironment characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These abnormalities fuel tumor progression, immunosuppression, and treatment resistance. In 2001, we proposed a novel hypothesis that the judicious use of antiangiogenesis agents—originally developed to starve tumors—could transiently normalize tumor vessels and improve the outcome of anticancer drugs administered during the window of normalization. In addition to providing preclinical and clinical evidence in support of this hypothesis, we also revealed the underlying molecular mechanisms. In parallel, we demonstrated that desmoplasia could also impair vascular function by compressing vessels, and that normalizing the extracellular matrix could improve vascular function and treatment outcome in both preclinical and clinical settings. Here, we summarize the progress made in understanding and applying the normalization concept to cancer and outline opportunities and challenges ahead to improve patient outcomes using various normalizing strategies." @default.
- W2914098003 created "2019-02-21" @default.
- W2914098003 creator A5015585176 @default.
- W2914098003 creator A5035082371 @default.
- W2914098003 creator A5049677254 @default.
- W2914098003 date "2019-02-10" @default.
- W2914098003 modified "2023-10-15" @default.
- W2914098003 title "Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges" @default.
- W2914098003 cites W1005746626 @default.
- W2914098003 cites W1487455823 @default.
- W2914098003 cites W1578283200 @default.
- W2914098003 cites W1603230122 @default.
- W2914098003 cites W1661176175 @default.
- W2914098003 cites W1810166418 @default.
- W2914098003 cites W1921704765 @default.
- W2914098003 cites W1964128680 @default.
- W2914098003 cites W1971119095 @default.
- W2914098003 cites W1975153720 @default.
- W2914098003 cites W1975959171 @default.
- W2914098003 cites W1977439064 @default.
- W2914098003 cites W1978172515 @default.
- W2914098003 cites W1981486151 @default.
- W2914098003 cites W1983225377 @default.
- W2914098003 cites W1983517349 @default.
- W2914098003 cites W1990253071 @default.
- W2914098003 cites W1990983926 @default.
- W2914098003 cites W1992112921 @default.
- W2914098003 cites W1992944027 @default.
- W2914098003 cites W1996912024 @default.
- W2914098003 cites W1998149120 @default.
- W2914098003 cites W1998266575 @default.
- W2914098003 cites W1998746346 @default.
- W2914098003 cites W2003773886 @default.
- W2914098003 cites W2005508881 @default.
- W2914098003 cites W2006202974 @default.
- W2914098003 cites W2010353217 @default.
- W2914098003 cites W2015609239 @default.
- W2914098003 cites W2021597202 @default.
- W2914098003 cites W2022540958 @default.
- W2914098003 cites W2024455227 @default.
- W2914098003 cites W2024903578 @default.
- W2914098003 cites W2025016054 @default.
- W2914098003 cites W2025106701 @default.
- W2914098003 cites W2028437938 @default.
- W2914098003 cites W2032995169 @default.
- W2914098003 cites W2033878276 @default.
- W2914098003 cites W2034126562 @default.
- W2914098003 cites W2034801324 @default.
- W2914098003 cites W2037342985 @default.
- W2914098003 cites W2037761545 @default.
- W2914098003 cites W2043967411 @default.
- W2914098003 cites W2048672748 @default.
- W2914098003 cites W2056574134 @default.
- W2914098003 cites W205706771 @default.
- W2914098003 cites W2062664804 @default.
- W2914098003 cites W2062875932 @default.
- W2914098003 cites W2066735451 @default.
- W2914098003 cites W2070636596 @default.
- W2914098003 cites W2071494920 @default.
- W2914098003 cites W2074898491 @default.
- W2914098003 cites W2077390445 @default.
- W2914098003 cites W2080202443 @default.
- W2914098003 cites W2085327953 @default.
- W2914098003 cites W2086834665 @default.
- W2914098003 cites W2088812649 @default.
- W2914098003 cites W2096487280 @default.
- W2914098003 cites W2102392974 @default.
- W2914098003 cites W2104300873 @default.
- W2914098003 cites W2106195219 @default.
- W2914098003 cites W2106664677 @default.
- W2914098003 cites W2114639921 @default.
- W2914098003 cites W2115820646 @default.
- W2914098003 cites W2121294718 @default.
- W2914098003 cites W2126163864 @default.
- W2914098003 cites W2130464657 @default.
- W2914098003 cites W2134431790 @default.
- W2914098003 cites W2135783949 @default.
- W2914098003 cites W2136023563 @default.
- W2914098003 cites W2137217704 @default.
- W2914098003 cites W2137541604 @default.
- W2914098003 cites W2137816700 @default.
- W2914098003 cites W2138378181 @default.
- W2914098003 cites W2139788242 @default.
- W2914098003 cites W2142104626 @default.
- W2914098003 cites W2146628652 @default.
- W2914098003 cites W2146706439 @default.
- W2914098003 cites W2147288982 @default.
- W2914098003 cites W2147535764 @default.
- W2914098003 cites W2154084248 @default.
- W2914098003 cites W2156906256 @default.
- W2914098003 cites W2158303916 @default.
- W2914098003 cites W2158449037 @default.
- W2914098003 cites W2159646566 @default.
- W2914098003 cites W2164899193 @default.
- W2914098003 cites W2165036434 @default.
- W2914098003 cites W2167455663 @default.
- W2914098003 cites W2167795547 @default.
- W2914098003 cites W2170249858 @default.