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- W2914106585 endingPage "240.e12" @default.
- W2914106585 startingPage "240.e1" @default.
- W2914106585 abstract "The purpose of this study was to develop an easy and minimally invasive assay to detect a plasma miRNA profile in frontotemporal dementia (FTD) patients, with the final aim of discriminating between FTD patients and healthy controls (HCs). After a global miRNA profiling, significant downregulation of miR-663a, miR-502-3p, and miR-206 (p = 0.0001, p = 0.0002, and p = 0.02 respectively) in FTD patients was confirmed when compared with HCs in a larger case-control sample. Moreover, miR-663a and miR-502-3p showed significant differences in both genders, whereas miR-206, only in male subjects. To obtain a discriminating measure between FTD patients and HCs, we calculated a combined score of the 3 miRNAs by applying a Bayesian approach and obtaining a classifier with an accuracy of 84.4%. Moreover, for men, combined miRNA levels showed an excellent sensitivity (100%) and a good specificity (87.5%) in distinguishing FTD patients from HCs. All these findings open new hypotheses in the pathophysiology and new perspectives in the diagnosis of a complex pathology as FTD." @default.
- W2914106585 created "2019-02-21" @default.
- W2914106585 creator A5004919781 @default.
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- W2914106585 creator A5090921652 @default.
- W2914106585 date "2019-12-01" @default.
- W2914106585 modified "2023-09-25" @default.
- W2914106585 title "Plasma microRNA profiling distinguishes patients with frontotemporal dementia from healthy subjects" @default.
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- W2914106585 doi "https://doi.org/10.1016/j.neurobiolaging.2019.01.024" @default.