Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914144156> ?p ?o ?g. }
- W2914144156 endingPage "842" @default.
- W2914144156 startingPage "835" @default.
- W2914144156 abstract "Abstract Invasive aspergillosis is a leading cause of morbidity and mortality among immunocompromised populations and is predicted to cause more than 200 000 life-threatening infections each year. Aspergillus fumigatus is the most prevalent pathogen isolated from patients with invasive aspergillosis, accounting for more than 60% of all cases. Currently, the only antifungal agents available with consistent activity against A. fumigatus are the mould-active triazoles and amphotericin B, of which the triazoles commonly represent both front-line and salvage therapeutic options. Unfortunately, the treatment of infections caused by A. fumigatus has recently been further complicated by the global emergence of triazole resistance among both clinical and environmental isolates. Mutations in the A. fumigatus sterol-demethylase gene cyp51A, overexpression of cyp51A and overexpression of efflux pump genes are all known to contribute to resistance, yet much of the triazole resistance among A. fumigatus still remains unexplained. Also lacking is clinical experience with therapeutic options for the treatment of triazole-resistant A. fumigatus infections and mortality associated with these infections remains unacceptably high. Thus, further research is greatly needed to both better understand the emerging threat of triazole-resistant A. fumigatus and to develop novel therapeutic strategies to combat these resistant infections." @default.
- W2914144156 created "2019-02-21" @default.
- W2914144156 creator A5007033300 @default.
- W2914144156 creator A5043553812 @default.
- W2914144156 creator A5059280370 @default.
- W2914144156 date "2018-12-17" @default.
- W2914144156 modified "2023-09-24" @default.
- W2914144156 title "Emerging threat of triazole-resistant Aspergillus fumigatus" @default.
- W2914144156 cites W1548791360 @default.
- W2914144156 cites W1889182392 @default.
- W2914144156 cites W1919380120 @default.
- W2914144156 cites W1964581982 @default.
- W2914144156 cites W1965263685 @default.
- W2914144156 cites W1967030141 @default.
- W2914144156 cites W1988273601 @default.
- W2914144156 cites W1991884176 @default.
- W2914144156 cites W2012538966 @default.
- W2914144156 cites W2023843703 @default.
- W2914144156 cites W2024259942 @default.
- W2914144156 cites W2026474096 @default.
- W2914144156 cites W2028189711 @default.
- W2914144156 cites W2033197762 @default.
- W2914144156 cites W2064316588 @default.
- W2914144156 cites W2079931127 @default.
- W2914144156 cites W2082695689 @default.
- W2914144156 cites W2098670497 @default.
- W2914144156 cites W2098823024 @default.
- W2914144156 cites W2100157937 @default.
- W2914144156 cites W2101244261 @default.
- W2914144156 cites W2104433838 @default.
- W2914144156 cites W2104743902 @default.
- W2914144156 cites W2107794472 @default.
- W2914144156 cites W2108741132 @default.
- W2914144156 cites W2112824490 @default.
- W2914144156 cites W2113498073 @default.
- W2914144156 cites W2114168745 @default.
- W2914144156 cites W2115118709 @default.
- W2914144156 cites W2118505677 @default.
- W2914144156 cites W2133932584 @default.
- W2914144156 cites W2138700722 @default.
- W2914144156 cites W2143760227 @default.
- W2914144156 cites W2146624456 @default.
- W2914144156 cites W2150247775 @default.
- W2914144156 cites W2157308892 @default.
- W2914144156 cites W2180529408 @default.
- W2914144156 cites W2189861011 @default.
- W2914144156 cites W2196289109 @default.
- W2914144156 cites W2225884786 @default.
- W2914144156 cites W2261554194 @default.
- W2914144156 cites W2285472607 @default.
- W2914144156 cites W2304795409 @default.
- W2914144156 cites W2352140081 @default.
- W2914144156 cites W2407446591 @default.
- W2914144156 cites W2470291098 @default.
- W2914144156 cites W2472624377 @default.
- W2914144156 cites W2473745709 @default.
- W2914144156 cites W2480320739 @default.
- W2914144156 cites W2483473788 @default.
- W2914144156 cites W2504680581 @default.
- W2914144156 cites W2505803812 @default.
- W2914144156 cites W2524621063 @default.
- W2914144156 cites W2555319609 @default.
- W2914144156 cites W2561005468 @default.
- W2914144156 cites W2565729619 @default.
- W2914144156 cites W2569875961 @default.
- W2914144156 cites W2574417950 @default.
- W2914144156 cites W2583467547 @default.
- W2914144156 cites W2599192510 @default.
- W2914144156 cites W2621329764 @default.
- W2914144156 cites W2623232822 @default.
- W2914144156 doi "https://doi.org/10.1093/jac/dky517" @default.
- W2914144156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6657284" @default.
- W2914144156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30561652" @default.
- W2914144156 hasPublicationYear "2018" @default.
- W2914144156 type Work @default.
- W2914144156 sameAs 2914144156 @default.
- W2914144156 citedByCount "39" @default.
- W2914144156 countsByYear W29141441562019 @default.
- W2914144156 countsByYear W29141441562020 @default.
- W2914144156 countsByYear W29141441562021 @default.
- W2914144156 countsByYear W29141441562022 @default.
- W2914144156 countsByYear W29141441562023 @default.
- W2914144156 crossrefType "journal-article" @default.
- W2914144156 hasAuthorship W2914144156A5007033300 @default.
- W2914144156 hasAuthorship W2914144156A5043553812 @default.
- W2914144156 hasAuthorship W2914144156A5059280370 @default.
- W2914144156 hasBestOaLocation W29141441562 @default.
- W2914144156 hasConcept C114851261 @default.
- W2914144156 hasConcept C178790620 @default.
- W2914144156 hasConcept C185592680 @default.
- W2914144156 hasConcept C200082930 @default.
- W2914144156 hasConcept C203014093 @default.
- W2914144156 hasConcept C2776391196 @default.
- W2914144156 hasConcept C2777907353 @default.
- W2914144156 hasConcept C2778566413 @default.
- W2914144156 hasConcept C2779175654 @default.
- W2914144156 hasConcept C2779548794 @default.
- W2914144156 hasConcept C2779629538 @default.