Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914153814> ?p ?o ?g. }
- W2914153814 abstract "Abstract Follicular helper T cells (Tfh) play critical roles instructing, and initiating T-cell dependent antibody responses. The underlying mechanisms that enhance their function is therefore critical for vaccine development. Here we apply gene array analysis identifying adenosine deaminase (ADA) as a key molecule that delineates a human Tfh helper program in proliferating circulating Tfh (cTfh) cells and Germinal Centers Tfh (GC-Tfh). ADA-1 expression and enzymatic activity are increased in efficient cTfh2-17/GC-Tfh cells. Exogenous ADA-1 enhances less efficient cTfh1 and pro-follicular Tfh PD-1+ CXCR5+ cells to provide B cell help, while pharmacological inhibition of ADA-1 activity impedes cTfh2-17/GC-Tfh function and diminished antibody response. Mechanistically, ADA-1 controls the Tfh program by influencing IL6/IL-2 production, controlling CD26 extracellular expression and could balance signals through adenosine receptors. Interestingly, dysfunctional Tfh from HIV infected-individual fail to regulate the ADA pathway. Thus, ADA-1 regulates human Tfh and represents a potential target for development of vaccine strategy." @default.
- W2914153814 created "2019-02-21" @default.
- W2914153814 creator A5002812964 @default.
- W2914153814 creator A5004383207 @default.
- W2914153814 creator A5027611345 @default.
- W2914153814 creator A5050456923 @default.
- W2914153814 creator A5054317446 @default.
- W2914153814 creator A5076232585 @default.
- W2914153814 creator A5076982151 @default.
- W2914153814 creator A5079485273 @default.
- W2914153814 date "2019-02-18" @default.
- W2914153814 modified "2023-09-25" @default.
- W2914153814 title "Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV" @default.
- W2914153814 cites W1495012795 @default.
- W2914153814 cites W183702388 @default.
- W2914153814 cites W1901976590 @default.
- W2914153814 cites W195484545 @default.
- W2914153814 cites W1969302149 @default.
- W2914153814 cites W1971743618 @default.
- W2914153814 cites W1975189275 @default.
- W2914153814 cites W1981597823 @default.
- W2914153814 cites W1981732254 @default.
- W2914153814 cites W1982540896 @default.
- W2914153814 cites W1982595765 @default.
- W2914153814 cites W1987076250 @default.
- W2914153814 cites W1988887233 @default.
- W2914153814 cites W1989197835 @default.
- W2914153814 cites W1998562159 @default.
- W2914153814 cites W2000028511 @default.
- W2914153814 cites W2001775594 @default.
- W2914153814 cites W2015200774 @default.
- W2914153814 cites W2016844693 @default.
- W2914153814 cites W2017219476 @default.
- W2914153814 cites W2022067754 @default.
- W2914153814 cites W2025077799 @default.
- W2914153814 cites W2030122155 @default.
- W2914153814 cites W2044428529 @default.
- W2914153814 cites W2051020804 @default.
- W2914153814 cites W2056222368 @default.
- W2914153814 cites W2065329851 @default.
- W2914153814 cites W2077791892 @default.
- W2914153814 cites W2079236755 @default.
- W2914153814 cites W2087179955 @default.
- W2914153814 cites W2096475468 @default.
- W2914153814 cites W2099268020 @default.
- W2914153814 cites W2117679109 @default.
- W2914153814 cites W2118274231 @default.
- W2914153814 cites W2133537577 @default.
- W2914153814 cites W2147365530 @default.
- W2914153814 cites W2150944106 @default.
- W2914153814 cites W2153816355 @default.
- W2914153814 cites W2157210912 @default.
- W2914153814 cites W2159945718 @default.
- W2914153814 cites W2160697532 @default.
- W2914153814 cites W2164549845 @default.
- W2914153814 cites W2169466773 @default.
- W2914153814 cites W2172074761 @default.
- W2914153814 cites W2172399299 @default.
- W2914153814 cites W2292051166 @default.
- W2914153814 cites W2308108739 @default.
- W2914153814 cites W2399997331 @default.
- W2914153814 cites W2413812514 @default.
- W2914153814 cites W2482434238 @default.
- W2914153814 cites W2505331449 @default.
- W2914153814 cites W2535610150 @default.
- W2914153814 cites W2550740111 @default.
- W2914153814 cites W2562199071 @default.
- W2914153814 cites W2577027008 @default.
- W2914153814 cites W2735891807 @default.
- W2914153814 cites W4250501680 @default.
- W2914153814 doi "https://doi.org/10.1038/s41467-019-08801-1" @default.
- W2914153814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6379489" @default.
- W2914153814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30778076" @default.
- W2914153814 hasPublicationYear "2019" @default.
- W2914153814 type Work @default.
- W2914153814 sameAs 2914153814 @default.
- W2914153814 citedByCount "20" @default.
- W2914153814 countsByYear W29141538142019 @default.
- W2914153814 countsByYear W29141538142020 @default.
- W2914153814 countsByYear W29141538142021 @default.
- W2914153814 countsByYear W29141538142022 @default.
- W2914153814 countsByYear W29141538142023 @default.
- W2914153814 crossrefType "journal-article" @default.
- W2914153814 hasAuthorship W2914153814A5002812964 @default.
- W2914153814 hasAuthorship W2914153814A5004383207 @default.
- W2914153814 hasAuthorship W2914153814A5027611345 @default.
- W2914153814 hasAuthorship W2914153814A5050456923 @default.
- W2914153814 hasAuthorship W2914153814A5054317446 @default.
- W2914153814 hasAuthorship W2914153814A5076232585 @default.
- W2914153814 hasAuthorship W2914153814A5076982151 @default.
- W2914153814 hasAuthorship W2914153814A5079485273 @default.
- W2914153814 hasBestOaLocation W29141538141 @default.
- W2914153814 hasConcept C14036430 @default.
- W2914153814 hasConcept C1491633281 @default.
- W2914153814 hasConcept C159654299 @default.
- W2914153814 hasConcept C203014093 @default.
- W2914153814 hasConcept C2776708503 @default.
- W2914153814 hasConcept C2776991684 @default.
- W2914153814 hasConcept C2778453870 @default.
- W2914153814 hasConcept C34628245 @default.