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- W2914156600 endingPage "1801578" @default.
- W2914156600 startingPage "1801578" @default.
- W2914156600 abstract "The extracellular matrix (ECM) is a complex and dynamic structural scaffold for cells within tissues and plays an important role in regulating cell function. Recently it has become appreciated that the ECM contains bioactive motifs that can directly modulate immune responses. This review describes strategies for engineering immunomodulatory biomaterials that utilize natural ECM-derived molecules and have the potential to harness the immune system for applications ranging from tissue regeneration to drug delivery. A top-down approach utilizes full-length ECM proteins, including collagen, fibrin, or hyaluronic acid-based materials, as well as matrices derived from decellularized tissue. These materials have the benefit of maintaining natural conformation and structure but are often heterogeneous and encumber precise control. By contrast, a bottom-up approach leverages immunomodulatory domains, such as Arg-Gly-Asp (RGD), matrix metalloproteinase (MMP)-sensitive peptides, or leukocyte-associated immunoglobulin-like receptor-1(LAIR-1) ligands, by incorporating them into synthetic materials. These materials have tunable control over immune cell functions and allow for combinatorial approaches. However, the synthetic approach lacks the full natural context of the original ECM protein. These two approaches provide a broad range of engineering techniques for immunomodulation through material interactions and hold the potential for the development of future therapeutic applications." @default.
- W2914156600 created "2019-02-21" @default.
- W2914156600 creator A5010645850 @default.
- W2914156600 creator A5013515186 @default.
- W2914156600 creator A5048045371 @default.
- W2914156600 creator A5054570777 @default.
- W2914156600 date "2019-02-04" @default.
- W2914156600 modified "2023-10-17" @default.
- W2914156600 title "Extracellular Matrix‐Based Strategies for Immunomodulatory Biomaterials Engineering" @default.
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