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• W2914169043 abstract "Background Uremic cardiomyopathy, characterized by left ventricular hypertrophy, diastolic dysfunction, and impaired myocardial strain, contributes to increased cardiovascular mortality in patients with CKD. Emerging evidence suggests a pathogenic role for T cells during chronic heart failure. Methods To determine whether T cells contribute to uremic cardiomyopathy pathogenesis, we modeled this condition by inducing CKD via 5/6th nephrectomy in mice. We used flow cytometry to assess expression of markers of T cell memory or activation by lymphocytes from CKD mice and controls, as well as lymphocyte capacity for cytokine production. Flow cytometry was also used to quantify immune cells isolated from heart tissue. To test effects of T cell depletion on cardiac function, we gave CKD mice anti-CD3 antibody injections to deplete T cells and compared heart function (assessed by echocardiography) with that of controls. Finally, we correlated T cell phenotypes with structural and functional measures on clinically acquired echocardiograms in children with CKD. Results Mice with CKD accumulated T cells bearing markers of memory differentiation (CD44 hi ) and activation (PD-1, KLRG1, OX40), as reported previously in human CKD. In addition, mice with CKD showed T cells infiltrating the heart. T cell depletion significantly improved both diastolic function and myocardial strain in CKD mice without altering hypertension or degree of renal dysfunction. In children with CKD, increasing frequency of T cells bearing activation markers PD-1 and/or CD57 was associated with worsening diastolic function on echocardiogram. Conclusions CKD results in an accumulation of proinflammatory T cells that appears to contribute to myocardial dysfunction." @default.
• W2914169043 created "2019-02-21" @default.
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• W2914169043 creator A5087476769 @default.
• W2914169043 date "2019-02-06" @default.
• W2914169043 modified "2023-10-17" @default.
• W2914169043 title "T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy" @default.
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• W2914169043 doi "https://doi.org/10.1681/asn.2017101138" @default.
• W2914169043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6405145" @default.
• W2914169043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30728178" @default.
• W2914169043 hasPublicationYear "2019" @default.
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