FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914187030> ?p ?o ?g. }

• W2914187030 endingPage "931" @default.
• W2914187030 startingPage "920" @default.
• W2914187030 abstract "Abstract Background Type 1 diabetes (T1D) is associated with delayed tissue healing and bone loss. Periodontal tissues during tooth movement (OTM) in T1D and under diabetic treatment are poorly understood. We aimed to study the effect of metformin as an add‐on to insulin therapy on periodontal structures during OTM in T1D rats. Methods Rats were divided into normoglycemic (NG, n = 20) and streptozotocin‐induced diabetic groups that were untreated (T1D, n = 20), treated with insulin (I‐T1D, n = 20), or treated with insulin plus metformin (IM‐T1D, n = 20). After 7 days of treatment, the first right upper molar (M1) was moved mesially. At days 0, 3, 7 and 14, the pattern of OTM and the periodontal tissues were analyzed by micro‐CT, histomorphometry, and immunohistochemistry for TRAP. Results In T1D, major osteoclastogenic activity and bone loss versus other groups were confirmed by a greater TRAP‐positive cell number and reabsorption surface on both the pressure and tension sides for 14 days ( p < 0.01). Additionally, we observed low bone volume density. Metformin plus insulin resulted in a daily insulin dose reduction and major glycemic control versus I‐T1D. Although no significant differences were observed between I‐T1D and IM‐T1D, the tooth displacement and inclination, periodontal ligament thickness, and alveolar bone density on the pressure side in IM‐T1D were similar to that of NG ( p > 0.05). Conclusion Antidiabetic treatment reduces severe periodontal damage during applied orthodontic force in T1D untreated rats. Metformin as an add‐on to insulin therapy resulted in glycemic control and a periodontal tissue response to orthodontic forces that was similar to that of normoglycemic rats." @default.
• W2914187030 created "2019-02-21" @default.
• W2914187030 creator A5000957152 @default.
• W2914187030 creator A5007093574 @default.
• W2914187030 creator A5020867458 @default.
• W2914187030 creator A5041337351 @default.
• W2914187030 creator A5050432299 @default.
• W2914187030 creator A5077358428 @default.
• W2914187030 creator A5090504593 @default.
• W2914187030 date "2019-02-15" @default.
• W2914187030 modified "2023-10-11" @default.
• W2914187030 title "Metformin as an add-on to insulin improves periodontal response during orthodontic tooth movement in type 1 diabetic rats" @default.
• W2914187030 cites W1534989352 @default.
• W2914187030 cites W1605596621 @default.
• W2914187030 cites W1948111189 @default.
• W2914187030 cites W1964611109 @default.
• W2914187030 cites W1968256850 @default.
• W2914187030 cites W1968727218 @default.
• W2914187030 cites W1971079719 @default.
• W2914187030 cites W1972409542 @default.
• W2914187030 cites W1992883070 @default.
• W2914187030 cites W1996666687 @default.
• W2914187030 cites W1998775755 @default.
• W2914187030 cites W2010835809 @default.
• W2914187030 cites W2019525387 @default.
• W2914187030 cites W2042859037 @default.
• W2914187030 cites W2045764192 @default.
• W2914187030 cites W2051135812 @default.
• W2914187030 cites W2053519532 @default.
• W2914187030 cites W2060675347 @default.
• W2914187030 cites W2073234691 @default.
• W2914187030 cites W2074689756 @default.
• W2914187030 cites W2078618341 @default.
• W2914187030 cites W2080044233 @default.
• W2914187030 cites W2083670461 @default.
• W2914187030 cites W2091272943 @default.
• W2914187030 cites W2092257809 @default.
• W2914187030 cites W2092778852 @default.
• W2914187030 cites W2108001469 @default.
• W2914187030 cites W2111365448 @default.
• W2914187030 cites W2115349613 @default.
• W2914187030 cites W2117239384 @default.
• W2914187030 cites W2155302992 @default.
• W2914187030 cites W2157747668 @default.
• W2914187030 cites W2169340729 @default.
• W2914187030 cites W2170542919 @default.
• W2914187030 cites W2173487135 @default.
• W2914187030 cites W2266734035 @default.
• W2914187030 cites W2275629034 @default.
• W2914187030 cites W2298273515 @default.
• W2914187030 cites W2600960936 @default.
• W2914187030 cites W2614429899 @default.
• W2914187030 cites W2621210046 @default.
• W2914187030 cites W2728566353 @default.
• W2914187030 cites W2750479320 @default.
• W2914187030 cites W2755614890 @default.
• W2914187030 cites W2794165852 @default.
• W2914187030 doi "https://doi.org/10.1002/jper.18-0140" @default.
• W2914187030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30698273" @default.
• W2914187030 hasPublicationYear "2019" @default.
• W2914187030 type Work @default.
• W2914187030 sameAs 2914187030 @default.
• W2914187030 citedByCount "3" @default.
• W2914187030 countsByYear W29141870302020 @default.
• W2914187030 countsByYear W29141870302021 @default.
• W2914187030 crossrefType "journal-article" @default.
• W2914187030 hasAuthorship W2914187030A5000957152 @default.
• W2914187030 hasAuthorship W2914187030A5007093574 @default.
• W2914187030 hasAuthorship W2914187030A5020867458 @default.
• W2914187030 hasAuthorship W2914187030A5041337351 @default.
• W2914187030 hasAuthorship W2914187030A5050432299 @default.
• W2914187030 hasAuthorship W2914187030A5077358428 @default.
• W2914187030 hasAuthorship W2914187030A5090504593 @default.
• W2914187030 hasConcept C126322002 @default.
• W2914187030 hasConcept C134018914 @default.
• W2914187030 hasConcept C151279780 @default.
• W2914187030 hasConcept C199343813 @default.
• W2914187030 hasConcept C202271784 @default.
• W2914187030 hasConcept C2779280383 @default.
• W2914187030 hasConcept C2779306644 @default.
• W2914187030 hasConcept C2780323712 @default.
• W2914187030 hasConcept C2781232474 @default.
• W2914187030 hasConcept C555293320 @default.
• W2914187030 hasConcept C71924100 @default.
• W2914187030 hasConceptScore W2914187030C126322002 @default.
• W2914187030 hasConceptScore W2914187030C134018914 @default.
• W2914187030 hasConceptScore W2914187030C151279780 @default.
• W2914187030 hasConceptScore W2914187030C199343813 @default.
• W2914187030 hasConceptScore W2914187030C202271784 @default.
• W2914187030 hasConceptScore W2914187030C2779280383 @default.
• W2914187030 hasConceptScore W2914187030C2779306644 @default.
• W2914187030 hasConceptScore W2914187030C2780323712 @default.
• W2914187030 hasConceptScore W2914187030C2781232474 @default.
• W2914187030 hasConceptScore W2914187030C555293320 @default.
• W2914187030 hasConceptScore W2914187030C71924100 @default.
• W2914187030 hasIssue "8" @default.
• W2914187030 hasLocation W29141870301 @default.
• W2914187030 hasLocation W29141870302 @default.

• next