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- W2914190513 endingPage "872" @default.
- W2914190513 startingPage "872" @default.
- W2914190513 abstract "Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI–FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 ± 0.36 μM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis." @default.
- W2914190513 created "2019-02-21" @default.
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- W2914190513 date "2019-02-18" @default.
- W2914190513 modified "2023-10-01" @default.
- W2914190513 title "Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico" @default.
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- W2914190513 doi "https://doi.org/10.3390/ijms20040872" @default.
- W2914190513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413047" @default.
- W2914190513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30781602" @default.
- W2914190513 hasPublicationYear "2019" @default.
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