FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914202007> ?p ?o ?g. }

• W2914202007 endingPage "e0211648" @default.
• W2914202007 startingPage "e0211648" @default.
• W2914202007 abstract "Background Despite the importance of platelet transfusions in treatment of hematologic cancer patients, the optimal platelet count threshold for prophylactic transfusion is unknown in sub-Saharan Africa. Methods We followed patients admitted to the Uganda Cancer Institute with a hematological malignancy in 3 sequential 4-month time-periods using incrementally lower thresholds for prophylactic platelet transfusion: platelet counts ≤ 30 x 109/L in period 1, ≤ 20 x 109/L in period 2, and ≤ 10 x 109/L in period 3. Clinically significant bleeding was defined as WHO grade ≥ 2 bleeding. We used generalized estimating equations (GEE) to compare the frequency of clinically significant bleeding and platelet transfusions by study period, adjusting for age, sex, cancer type, chemotherapy, baseline platelet count, and baseline hemoglobin. Results Overall, 188 patients were enrolled. The median age was 22 years (range 1–80). Platelet transfusions were given to 42% of patients in period 1, 55% in period 2, and 45% in period 3. These transfusions occurred on 8% of days in period 1, 12% in period 2, and 8% in period 3. In adjusted models, period 3 had significantly fewer transfusions than period 1 (RR = 0.6, 95% CI 0.4–0.9; p = 0.01) and period 2 (RR = 0.5, 95% CI 0.4–0.7; p<0.001). Eighteen patients (30%) had clinically significant bleeding on at least one day in period 1, 23 (30%) in period 2, and 15 (23%) in period 3. Clinically significant bleeding occurred on 8% of patient-days in period 1, 9% in period 2, and 5% in period 3 (adjusted p = 0.41). Thirteen (21%) patients died in period 1, 15 (22%) in period 2, and 11 (19%) in period 3 (adjusted p = 0.96). Conclusion Lowering the threshold for platelet transfusion led to fewer transfusions and did not change the incidence of clinically significant bleeding or mortality, suggesting that a threshold of 10 x 109/L platelets, used in resource-rich countries, may be implemented as a safe level for transfusions in sub-Saharan Africa." @default.
• W2914202007 created "2019-02-21" @default.
• W2914202007 creator A5010051899 @default.
• W2914202007 creator A5011406448 @default.
• W2914202007 creator A5035455400 @default.
• W2914202007 creator A5039566649 @default.
• W2914202007 creator A5045484400 @default.
• W2914202007 creator A5047352358 @default.
• W2914202007 creator A5052928140 @default.
• W2914202007 creator A5054523136 @default.
• W2914202007 creator A5085214892 @default.
• W2914202007 creator A5086253827 @default.
• W2914202007 date "2019-02-06" @default.
• W2914202007 modified "2023-10-01" @default.
• W2914202007 title "How low can you go: What is the safe threshold for platelet transfusions in patients with hematologic malignancy in sub-Saharan Africa" @default.
• W2914202007 cites W1546852945 @default.
• W2914202007 cites W1570845379 @default.
• W2914202007 cites W1574141134 @default.
• W2914202007 cites W1904761839 @default.
• W2914202007 cites W1966749562 @default.
• W2914202007 cites W1981989535 @default.
• W2914202007 cites W1983183179 @default.
• W2914202007 cites W2006484291 @default.
• W2914202007 cites W2010333741 @default.
• W2914202007 cites W2017646413 @default.
• W2914202007 cites W2022706283 @default.
• W2914202007 cites W2030938356 @default.
• W2914202007 cites W2039223350 @default.
• W2914202007 cites W2048887884 @default.
• W2914202007 cites W2069801787 @default.
• W2914202007 cites W2078973132 @default.
• W2914202007 cites W2080572779 @default.
• W2914202007 cites W2105506225 @default.
• W2914202007 cites W2135796724 @default.
• W2914202007 cites W2145125317 @default.
• W2914202007 cites W2147290071 @default.
• W2914202007 cites W2151684406 @default.
• W2914202007 cites W2152982768 @default.
• W2914202007 cites W2158441687 @default.
• W2914202007 cites W2161092175 @default.
• W2914202007 cites W2166770716 @default.
• W2914202007 cites W2170123795 @default.
• W2914202007 cites W2186844863 @default.
• W2914202007 cites W2312239978 @default.
• W2914202007 cites W2339005914 @default.
• W2914202007 cites W2467632814 @default.
• W2914202007 cites W4241306296 @default.
• W2914202007 cites W4252764851 @default.
• W2914202007 doi "https://doi.org/10.1371/journal.pone.0211648" @default.
• W2914202007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364911" @default.
• W2914202007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30726290" @default.
• W2914202007 hasPublicationYear "2019" @default.
• W2914202007 type Work @default.
• W2914202007 sameAs 2914202007 @default.
• W2914202007 citedByCount "3" @default.
• W2914202007 countsByYear W29142020072020 @default.
• W2914202007 countsByYear W29142020072021 @default.
• W2914202007 crossrefType "journal-article" @default.
• W2914202007 hasAuthorship W2914202007A5010051899 @default.
• W2914202007 hasAuthorship W2914202007A5011406448 @default.
• W2914202007 hasAuthorship W2914202007A5035455400 @default.
• W2914202007 hasAuthorship W2914202007A5039566649 @default.
• W2914202007 hasAuthorship W2914202007A5045484400 @default.
• W2914202007 hasAuthorship W2914202007A5047352358 @default.
• W2914202007 hasAuthorship W2914202007A5052928140 @default.
• W2914202007 hasAuthorship W2914202007A5054523136 @default.
• W2914202007 hasAuthorship W2914202007A5085214892 @default.
• W2914202007 hasAuthorship W2914202007A5086253827 @default.
• W2914202007 hasBestOaLocation W29142020071 @default.
• W2914202007 hasConcept C105795698 @default.
• W2914202007 hasConcept C126322002 @default.
• W2914202007 hasConcept C141071460 @default.
• W2914202007 hasConcept C27403532 @default.
• W2914202007 hasConcept C2776689292 @default.
• W2914202007 hasConcept C2779399171 @default.
• W2914202007 hasConcept C2909984355 @default.
• W2914202007 hasConcept C33923547 @default.
• W2914202007 hasConcept C53084192 @default.
• W2914202007 hasConcept C71924100 @default.
• W2914202007 hasConcept C89560881 @default.
• W2914202007 hasConcept C90924648 @default.
• W2914202007 hasConceptScore W2914202007C105795698 @default.
• W2914202007 hasConceptScore W2914202007C126322002 @default.
• W2914202007 hasConceptScore W2914202007C141071460 @default.
• W2914202007 hasConceptScore W2914202007C27403532 @default.
• W2914202007 hasConceptScore W2914202007C2776689292 @default.
• W2914202007 hasConceptScore W2914202007C2779399171 @default.
• W2914202007 hasConceptScore W2914202007C2909984355 @default.
• W2914202007 hasConceptScore W2914202007C33923547 @default.
• W2914202007 hasConceptScore W2914202007C53084192 @default.
• W2914202007 hasConceptScore W2914202007C71924100 @default.
• W2914202007 hasConceptScore W2914202007C89560881 @default.
• W2914202007 hasConceptScore W2914202007C90924648 @default.
• W2914202007 hasFunder F4320337356 @default.
• W2914202007 hasIssue "2" @default.
• W2914202007 hasLocation W29142020071 @default.
• W2914202007 hasLocation W29142020072 @default.
• W2914202007 hasLocation W29142020073 @default.

• next