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- W291420217 abstract "This chapter describes primary lateral sclerosis (PLS). For PLS, there may be an exclusive involvement of the lateral tract of the spinal cord. The disease progresses to marked disability in all four limbs, irrespective of the site of onset. The clinical, electrophysiological, and pathological investigations suggest that the disease has a heterogeneous clinical presentation and that degeneration is not restricted to the central motor system (CNS). Electrophysiological studies such as motor unit estimates (MUNE) and needle electromyography (EMG) support the occurrence of lower motor neuron disease in PLS. In some patients with an initial diagnosis of PLS, the disease evolves into classical amyotrophic lateral sclerosis (ALS) with lower motor neuron signs. The imaging studies for PLS include magnetic resonance imaging (MRI) and positron emission tomography (PET) studies. The diagnosis of PLS can be entertained if the disease is of adult onset and insidiously progressive over five years. There is no specific treatment for PLS. Treatment strategies remain largely symptomatic with specific attention to spasticity, inappropriate laughing and crying, urinary urgency, and pain." @default.
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- W291420217 date "2004-01-01" @default.
- W291420217 modified "2023-09-26" @default.
- W291420217 title "Primary lateral sclerosis" @default.
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- W291420217 doi "https://doi.org/10.1016/s1567-4231(04)04036-5" @default.
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