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- W2914208308 abstract "BACKGROUND Many studies evaluating blood flow and oxygen partial pressure (P o 2 ) do not directly measure both parameters, are confined to few locations/microvessels, and depend on investigator's selection of measuring sites. Moreover, clinically/physiologically relevant systemic parameters are not simultaneously recorded. We implemented an automated system for prolonged blood flow/P o 2 acquisition in large areas while collecting relevant systemic information. METHODS In anesthetized animals, cardiorespiratory parameters were continuously recorded. Other data were collected at baseline and hourly after 4 hours of hemorrhagic shock. A cremaster muscle was spread over a pedestal fixed to a motorized stage. One 2-dimensional tissue scan allowed 16 noninvasive P o 2 measurements using oxygen-dependent phosphorescence quenching and fiber optics. Blood flow was estimated using laser speckle contrast imaging in the same areas used for P o 2 measurements. At each timepoint, blood was sampled for extensive biochemistry/coagulation profile. RESULTS The system was used successfully by different operators. A set of flow/P o 2 measurements was completed in less than 90 seconds. Muscle flow and P o 2 correlated with some but not several systemic parameters, emphasizing the importance of performing both local and systemic evaluations. CONCLUSION System advantages include integration between local and over 40 systemic parameters, unbiased data collection/analysis, improved performance/sampled area, easy expansion, implementation and maintenance, no customized programming, and simplified training. Combining this system with trauma/prolonged HS models will enhance our ability to investigate tissue stability and select better resuscitation strategies to improve outcomes and survival. LEVEL OF EVIDENCE Diagnostic test, level V." @default.
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- W2914208308 date "2019-01-28" @default.
- W2914208308 modified "2023-10-14" @default.
- W2914208308 title "Automated noninvasive evaluation of blood flow and oxygenation in rats integrated with systemic physiological monitoring" @default.
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- W2914208308 doi "https://doi.org/10.1097/ta.0000000000002199" @default.
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