Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914215092> ?p ?o ?g. }
- W2914215092 endingPage "191" @default.
- W2914215092 startingPage "181" @default.
- W2914215092 abstract "The aim of this research is to utilize a hybrid system of liposomal doxorubicin (DOX-Lip) loaded thermogel (DOX-Lip-Gel) to realize the steady sustained delivery of doxorubicin (DOX), a small hydrophilic drug, for the treatment of breast cancer locally. Herein, liposomal doxorubicin was prepared via the traditional film dispersion method with the particle size of 75 nm and drug entrapment efficiency of 86%. And, the triblock copolymer of poly (D, L-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly (D, L-lactide -co-glycolide) (PLGA-PEG-PLGA) was synthesized via ring-opening polymerization to prepare the thermosensitive hydrogel through dissolving the polymers in DOX-Lip solution. The liposome loaded hydrogel was in a sol state at room temperature and converted into the gel state at body temperature and would degrade gradually during the time in vivo. The drug release of DOX out of DOX-Lip-Gel could be in a steady sustained manner up to 11 days without significant burst release as compared to that of DOX-loaded hydrogel (DOX-Gel). An orthotopic breast cancer model was adopted to evaluate the in vivo antitumor efficacy. And, the results revealed DOX-Lip-Gel had better antitumor efficiency as well as lower side effects." @default.
- W2914215092 created "2019-02-21" @default.
- W2914215092 creator A5005372243 @default.
- W2914215092 creator A5025964613 @default.
- W2914215092 creator A5051764594 @default.
- W2914215092 creator A5054109175 @default.
- W2914215092 creator A5056624509 @default.
- W2914215092 creator A5064038244 @default.
- W2914215092 creator A5074679765 @default.
- W2914215092 date "2019-01-27" @default.
- W2914215092 modified "2023-10-16" @default.
- W2914215092 title "Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer" @default.
- W2914215092 cites W1535876276 @default.
- W2914215092 cites W1549811736 @default.
- W2914215092 cites W1966748944 @default.
- W2914215092 cites W1967242750 @default.
- W2914215092 cites W1983032431 @default.
- W2914215092 cites W1986294502 @default.
- W2914215092 cites W1993836571 @default.
- W2914215092 cites W2001881925 @default.
- W2914215092 cites W2018708674 @default.
- W2914215092 cites W2032961593 @default.
- W2914215092 cites W2034541607 @default.
- W2914215092 cites W2036944284 @default.
- W2914215092 cites W2039350685 @default.
- W2914215092 cites W2041208664 @default.
- W2914215092 cites W2053272730 @default.
- W2914215092 cites W2060493851 @default.
- W2914215092 cites W2061369620 @default.
- W2914215092 cites W2074630757 @default.
- W2914215092 cites W2077116757 @default.
- W2914215092 cites W2080047588 @default.
- W2914215092 cites W2140124527 @default.
- W2914215092 cites W2154309902 @default.
- W2914215092 cites W2168972911 @default.
- W2914215092 cites W2276834492 @default.
- W2914215092 cites W2300671107 @default.
- W2914215092 cites W2315490410 @default.
- W2914215092 cites W2519536988 @default.
- W2914215092 cites W2525338197 @default.
- W2914215092 cites W2536753591 @default.
- W2914215092 cites W2569572387 @default.
- W2914215092 cites W2601641718 @default.
- W2914215092 cites W2610634235 @default.
- W2914215092 cites W2618771951 @default.
- W2914215092 cites W2691125521 @default.
- W2914215092 cites W2744578405 @default.
- W2914215092 cites W2746632521 @default.
- W2914215092 cites W2770498164 @default.
- W2914215092 cites W2793491122 @default.
- W2914215092 cites W2801652044 @default.
- W2914215092 cites W2805908425 @default.
- W2914215092 cites W2808280215 @default.
- W2914215092 cites W2883677247 @default.
- W2914215092 cites W423273973 @default.
- W2914215092 doi "https://doi.org/10.1080/21691401.2018.1548470" @default.
- W2914215092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30686051" @default.
- W2914215092 hasPublicationYear "2019" @default.
- W2914215092 type Work @default.
- W2914215092 sameAs 2914215092 @default.
- W2914215092 citedByCount "72" @default.
- W2914215092 countsByYear W29142150922019 @default.
- W2914215092 countsByYear W29142150922020 @default.
- W2914215092 countsByYear W29142150922021 @default.
- W2914215092 countsByYear W29142150922022 @default.
- W2914215092 countsByYear W29142150922023 @default.
- W2914215092 crossrefType "journal-article" @default.
- W2914215092 hasAuthorship W2914215092A5005372243 @default.
- W2914215092 hasAuthorship W2914215092A5025964613 @default.
- W2914215092 hasAuthorship W2914215092A5051764594 @default.
- W2914215092 hasAuthorship W2914215092A5054109175 @default.
- W2914215092 hasAuthorship W2914215092A5056624509 @default.
- W2914215092 hasAuthorship W2914215092A5064038244 @default.
- W2914215092 hasAuthorship W2914215092A5074679765 @default.
- W2914215092 hasBestOaLocation W29142150921 @default.
- W2914215092 hasConcept C10138342 @default.
- W2914215092 hasConcept C136229726 @default.
- W2914215092 hasConcept C141071460 @default.
- W2914215092 hasConcept C150903083 @default.
- W2914215092 hasConcept C155672457 @default.
- W2914215092 hasConcept C162324750 @default.
- W2914215092 hasConcept C171250308 @default.
- W2914215092 hasConcept C178790620 @default.
- W2914215092 hasConcept C185154212 @default.
- W2914215092 hasConcept C185592680 @default.
- W2914215092 hasConcept C192562407 @default.
- W2914215092 hasConcept C207001950 @default.
- W2914215092 hasConcept C2776694085 @default.
- W2914215092 hasConcept C2777516009 @default.
- W2914215092 hasConcept C2779820397 @default.
- W2914215092 hasConcept C2780165375 @default.
- W2914215092 hasConcept C2781303535 @default.
- W2914215092 hasConcept C54400483 @default.
- W2914215092 hasConcept C71924100 @default.
- W2914215092 hasConcept C86803240 @default.
- W2914215092 hasConceptScore W2914215092C10138342 @default.
- W2914215092 hasConceptScore W2914215092C136229726 @default.
- W2914215092 hasConceptScore W2914215092C141071460 @default.