Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914246542> ?p ?o ?g. }
- W2914246542 endingPage "5772" @default.
- W2914246542 startingPage "5750" @default.
- W2914246542 abstract "Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of cancer cells. Inhibitor of apoptosis proteins (IAPs) is a class of key apoptosis regulators that promote cancer cell resistant to apoptosis, particularly in cancer treatment. Disrupting the binding of IAPs with their functional partners therefore is a promising strategy to restore the apoptotic response to proapoptotic stimuli, particularly those introduced by standard cancer therapies. The most successful example is the use of small molecules to mimic the IAP-binding motif of an endogenous IAP antagonist, second mitochondria-derived activator of caspase (SMAC). Here we will review the functions of IAPs, the structural interactions of IAPs with SMAC, four generations of SMAC-mimetic IAP antagonists, and representative antagonists in clinical evaluations, focusing on research articles over the past 15 years. Outlooks and perspectives on the associated challenges are provided as well." @default.
- W2914246542 created "2019-02-21" @default.
- W2914246542 creator A5001506838 @default.
- W2914246542 creator A5001631388 @default.
- W2914246542 creator A5004206357 @default.
- W2914246542 creator A5005969908 @default.
- W2914246542 creator A5045099804 @default.
- W2914246542 creator A5047452454 @default.
- W2914246542 creator A5049872559 @default.
- W2914246542 creator A5091650806 @default.
- W2914246542 date "2019-01-24" @default.
- W2914246542 modified "2023-09-30" @default.
- W2914246542 title "Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives" @default.
- W2914246542 cites W1011422075 @default.
- W2914246542 cites W1203651314 @default.
- W2914246542 cites W1492310138 @default.
- W2914246542 cites W1492587973 @default.
- W2914246542 cites W1500271849 @default.
- W2914246542 cites W1725759174 @default.
- W2914246542 cites W1872257220 @default.
- W2914246542 cites W1948376788 @default.
- W2914246542 cites W1961949729 @default.
- W2914246542 cites W1965020333 @default.
- W2914246542 cites W1966472904 @default.
- W2914246542 cites W1969796729 @default.
- W2914246542 cites W1970010835 @default.
- W2914246542 cites W1970433780 @default.
- W2914246542 cites W1970628654 @default.
- W2914246542 cites W1971028883 @default.
- W2914246542 cites W1973462203 @default.
- W2914246542 cites W1975506525 @default.
- W2914246542 cites W1976353819 @default.
- W2914246542 cites W1979790122 @default.
- W2914246542 cites W1981596082 @default.
- W2914246542 cites W1986320887 @default.
- W2914246542 cites W1988013217 @default.
- W2914246542 cites W1989277510 @default.
- W2914246542 cites W1989525171 @default.
- W2914246542 cites W1993470980 @default.
- W2914246542 cites W1994851993 @default.
- W2914246542 cites W1995079678 @default.
- W2914246542 cites W1996066245 @default.
- W2914246542 cites W1998918148 @default.
- W2914246542 cites W2002645985 @default.
- W2914246542 cites W2003144224 @default.
- W2914246542 cites W2003926188 @default.
- W2914246542 cites W2004611844 @default.
- W2914246542 cites W2005572311 @default.
- W2914246542 cites W2007071412 @default.
- W2914246542 cites W2008443832 @default.
- W2914246542 cites W2008842667 @default.
- W2914246542 cites W2013933514 @default.
- W2914246542 cites W2014357769 @default.
- W2914246542 cites W2014569891 @default.
- W2914246542 cites W2015273986 @default.
- W2914246542 cites W2019005133 @default.
- W2914246542 cites W2019954416 @default.
- W2914246542 cites W2020857691 @default.
- W2914246542 cites W2023056845 @default.
- W2914246542 cites W2025128734 @default.
- W2914246542 cites W2025522492 @default.
- W2914246542 cites W2033492998 @default.
- W2914246542 cites W2033510349 @default.
- W2914246542 cites W2039234084 @default.
- W2914246542 cites W2040370168 @default.
- W2914246542 cites W2042409437 @default.
- W2914246542 cites W2046836366 @default.
- W2914246542 cites W2047219659 @default.
- W2914246542 cites W2049464805 @default.
- W2914246542 cites W2052853635 @default.
- W2914246542 cites W2053046411 @default.
- W2914246542 cites W2053308358 @default.
- W2914246542 cites W2053550021 @default.
- W2914246542 cites W2054717287 @default.
- W2914246542 cites W2055568018 @default.
- W2914246542 cites W2061543400 @default.
- W2914246542 cites W2061561620 @default.
- W2914246542 cites W2063598536 @default.
- W2914246542 cites W2063690467 @default.
- W2914246542 cites W2064235684 @default.
- W2914246542 cites W2064299413 @default.
- W2914246542 cites W2064635014 @default.
- W2914246542 cites W2065818103 @default.
- W2914246542 cites W2069766232 @default.
- W2914246542 cites W2069800916 @default.
- W2914246542 cites W2072385276 @default.
- W2914246542 cites W2078941943 @default.
- W2914246542 cites W2080207536 @default.
- W2914246542 cites W2080916979 @default.
- W2914246542 cites W2087968540 @default.
- W2914246542 cites W2088543522 @default.
- W2914246542 cites W2091269867 @default.
- W2914246542 cites W2093556522 @default.
- W2914246542 cites W2100067355 @default.
- W2914246542 cites W2102403951 @default.
- W2914246542 cites W2103092174 @default.
- W2914246542 cites W2107890932 @default.
- W2914246542 cites W2116609506 @default.