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• W2914272305 startingPage "592" @default.
• W2914272305 abstract "Successful reproduction in female mammals is precisely timed and must be able to withstand the metabolic demand of pregnancy and lactation. We show that kisspeptin-expressing neurons in the arcuate hypothalamus (Kiss1ARH) of female mice control the daily timing of food intake, along with the circadian regulation of locomotor activity, sleep, and core body temperature. Toxin-induced silencing of Kiss1ARH neurons shifts wakefulness and food consumption to the light phase and induces weight gain. Toxin-silenced mice are less physically active and have attenuated temperature rhythms. Because the rhythm of the master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1ARH neurons signal to neurons downstream of the master clock to modulate the output of the SCN. We conclude that, in addition to their well-established role in regulating fertility, Kiss1ARH neurons are a critical component of the hypothalamic circadian oscillator network that times overt rhythms of physiology and behavior." @default.
• W2914272305 created "2019-02-21" @default.
• W2914272305 creator A5009746099 @default.
• W2914272305 creator A5038665897 @default.
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• W2914272305 creator A5055765486 @default.
• W2914272305 creator A5079511477 @default.
• W2914272305 creator A5079869230 @default.
• W2914272305 creator A5082692793 @default.
• W2914272305 date "2019-02-01" @default.
• W2914272305 modified "2023-10-15" @default.
• W2914272305 title "Kisspeptin Neurons in the Arcuate Nucleus of the Hypothalamus Orchestrate Circadian Rhythms and Metabolism" @default.
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