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• W2914278534 abstract "Mollugo pentaphylla L. (Molluginaceae) extract (MPE) has been reported to have anti-inflammatory effect on MSU-induced gouty arthritis in a mouse model.This study examined the anti-inflammatory activities of an MPE in vitro and anti-osteoarthritis effects on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in vivo.The dried whole plants of M. pentaphylla were extracted with 70% ethanol under reflux. The anti-inflammatory effect of MPE was evaluated in vitro in lipopolysaccharide (LPS)-treated RAW264.7 cells. The anti-osteoarthritic effect of MPE was investigated in a Sprague-Dawley rat model of MIA-induced OA. Each seven male rats were orally administered MPE (75, 150 or 300 mg/kg) or the positive control drug indomethacin (1 mg/kg) 3 days before MIA injection and once daily for 11 days thereafter. After the treatment with MPE, no evidence of systemic adverse effects was observed in any study group.MPE exhibited anti-inflammatory activity via inhibition of the production of NO (57.8%), PGE2 (97.1%) and IL-6 (93.2%) in LPS-treated RAW264.7 cells at 200 μg/mL. In addition, MPE suppressed IL-1β (60.9%), TNF-α (37.9%) and IL- 6 (40.9%) production and suppressed the synthesis of MMP-2, MMP-9 and COX-2 in the MIA-induced OA rat model.These results demonstrate that MPE exerts potent anti-inflammatory activities and protects cartilage in an OA rat model. This might be a potential candidate for therapeutic OA treatment." @default.
• W2914278534 created "2019-02-21" @default.
• W2914278534 creator A5006810282 @default.
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• W2914278534 date "2019-01-01" @default.
• W2914278534 modified "2023-10-18" @default.
• W2914278534 title "Anti-inflammatory and anti-osteoarthritis effect of <i>Mollugo pentaphylla</i> extract" @default.
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• W2914278534 doi "https://doi.org/10.1080/13880209.2018.1557700" @default.
• W2914278534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30707846" @default.
• W2914278534 hasPublicationYear "2019" @default.
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