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- W2914297908 abstract "Background To determine overall benefit-risk, we examined the effect of single inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI and FF/VI on the composite outcome of acute exacerbation of COPD or pneumonia in the IMPACT study (NCT02164513, CTT116855), a 52 week, randomized, multicentre study in patients with symptomatic COPD and a history of exacerbations Methods We defined two composite outcomes: time to first moderate (required antibiotics and/or oral/systemic corticosteroids)/severe (required hospitalisation) exacerbation or pneumonia; and time to first severe exacerbation/hospitalised pneumonia. Analyses were based on a proportional hazards model. Results Moderate/severe exacerbations occurred in 47% of patients randomized to FF/UMEC/VI, 49% in those randomized to FF/VI and 50% in those randomized to UMEC/VI. Pneumonias occurred in 8%, 7%, and 5% of patients in these groups, respectively. FF/UMEC/VI reduced the risk of first moderate/severe exacerbation or pneumonia vs FF/VI by 13.2% (95%CI 7.8%–18.3%; p Conclusion These composite exacerbation/pneumonia outcomes support a favourable benefit-risk profile of once-daily FF/UMEC/VI compared with FF/VI and UMEC/VI in patients with moderate to severe COPD and a history of exacerbations. Funding GSK (CTT116855); This ENCORE abstract will be presented as a poster at the 2018 European Respiratory Society Meeting in September." @default.
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- W2914297908 date "2018-12-01" @default.
- W2914297908 modified "2023-09-26" @default.
- W2914297908 title "P248 Risk of exacerbation and pneumonia with single inhaler triple versus dual therapy in IMPACT" @default.
- W2914297908 doi "https://doi.org/10.1136/thorax-2018-212555.404" @default.
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