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- W2914301545 abstract "Toll-like receptors (TLRs) are pattern-recognition receptors that detect a wide variety of microbial pathogens for the initiation of host defense immunological responses. Thirteen TLRs have been identified in mammals, and teleosts contain 22 mammalian or non-mammalian TLRs. Of these, TLR9 and TLR21 are the cytosine-phosphate-guanosine-oligodeoxynucleotides (CpG-ODNs) recognition TLRs in teleosts. TLR9 is a mammalian TLR expressed in teleost but not in the avian species. TLR21 is a non-mammalian TLR expressed in both teleost and the avian species. Synthetic CpG-ODNs are potent immunostimulants that are being studied for their application against tumors, allergies, and infectious diseases, and as a vaccine adjuvant in humans. The immunostimulatory effects of CpG-ODNs as vaccine adjuvants and their antimicrobial function in domestic animals and teleosts are also being investigated. Most of our current knowledge about the molecular basis for the immunostimulatory activity of CpG-ODNs comes from earlier studies of the interaction between CpG-ODN and TLR9. More recent studies indicate that in addition to TLR9, TLR21 is another receptor for CpG-ODN recognition in teleosts to initiate immune responses. Whether these two receptors have differential functions in mediating the immunostimulatory activity of CpG-ODN in teleost has not been well-studied. Nevertheless, the existence of two recognition TLRs suggests that the molecular basis for the immunostimulatory activity of CpG-ODN in teleosts is different and more complex than in mammals. This article reviews the current knowledge of TLR9 and TLR21 activation by CpG-ODNs. The key points that need to be considered for CpG-ODNs as immunostimulants with maximum effectiveness in activation of immune responses in teleosts are discussed. This includes the structure/activity relationship of CpG-ODN activities for TLR9 and TLR21, the structure/functional relationship of these two TLRs, and differential expression levels and tissue distributions for these two TLRs." @default.
- W2914301545 created "2019-02-21" @default.
- W2914301545 creator A5010435147 @default.
- W2914301545 creator A5021561362 @default.
- W2914301545 creator A5023494911 @default.
- W2914301545 creator A5028637363 @default.
- W2914301545 creator A5074157691 @default.
- W2914301545 date "2019-02-08" @default.
- W2914301545 modified "2023-10-18" @default.
- W2914301545 title "Immunostimulatory Activities of CpG-Oligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21" @default.
- W2914301545 cites W1483162601 @default.
- W2914301545 cites W1489949286 @default.
- W2914301545 cites W1505229526 @default.
- W2914301545 cites W1514540900 @default.
- W2914301545 cites W1519633296 @default.
- W2914301545 cites W1588809288 @default.
- W2914301545 cites W1612465238 @default.
- W2914301545 cites W1622088669 @default.
- W2914301545 cites W1733534154 @default.
- W2914301545 cites W1845785449 @default.
- W2914301545 cites W1963937775 @default.
- W2914301545 cites W1964531685 @default.
- W2914301545 cites W1964575258 @default.
- W2914301545 cites W1965780520 @default.
- W2914301545 cites W1966892322 @default.
- W2914301545 cites W1968435842 @default.
- W2914301545 cites W1968693613 @default.
- W2914301545 cites W1969072247 @default.
- W2914301545 cites W1970100427 @default.
- W2914301545 cites W1971254306 @default.
- W2914301545 cites W1971378778 @default.
- W2914301545 cites W1972140057 @default.
- W2914301545 cites W1972147768 @default.
- W2914301545 cites W1973157062 @default.
- W2914301545 cites W1983470819 @default.
- W2914301545 cites W1983959087 @default.
- W2914301545 cites W1984618863 @default.
- W2914301545 cites W1987380905 @default.
- W2914301545 cites W1992469588 @default.
- W2914301545 cites W1992875583 @default.
- W2914301545 cites W1993878900 @default.
- W2914301545 cites W1994391392 @default.
- W2914301545 cites W1995586746 @default.
- W2914301545 cites W1995872536 @default.
- W2914301545 cites W1997376727 @default.
- W2914301545 cites W1998612872 @default.
- W2914301545 cites W1998643282 @default.
- W2914301545 cites W1998741449 @default.
- W2914301545 cites W2000282395 @default.
- W2914301545 cites W2000882026 @default.
- W2914301545 cites W2001356425 @default.
- W2914301545 cites W2004194243 @default.
- W2914301545 cites W2005174517 @default.
- W2914301545 cites W2006727124 @default.
- W2914301545 cites W2007042209 @default.
- W2914301545 cites W2008152503 @default.
- W2914301545 cites W2010083224 @default.
- W2914301545 cites W2016785655 @default.
- W2914301545 cites W2016862474 @default.
- W2914301545 cites W2017115181 @default.
- W2914301545 cites W2017267708 @default.
- W2914301545 cites W2019077744 @default.
- W2914301545 cites W2021054616 @default.
- W2914301545 cites W2025345914 @default.
- W2914301545 cites W2027759112 @default.
- W2914301545 cites W2033441782 @default.
- W2914301545 cites W2033926771 @default.
- W2914301545 cites W2043143775 @default.
- W2914301545 cites W2043544091 @default.
- W2914301545 cites W2047366876 @default.
- W2914301545 cites W2047376205 @default.
- W2914301545 cites W2048069351 @default.
- W2914301545 cites W2051026238 @default.
- W2914301545 cites W2057027223 @default.
- W2914301545 cites W2061570825 @default.
- W2914301545 cites W2062091239 @default.
- W2914301545 cites W2062350041 @default.
- W2914301545 cites W2065193095 @default.
- W2914301545 cites W2066124691 @default.
- W2914301545 cites W2067359484 @default.
- W2914301545 cites W2068816623 @default.
- W2914301545 cites W2069394593 @default.
- W2914301545 cites W2069630043 @default.
- W2914301545 cites W2069981713 @default.
- W2914301545 cites W2074991973 @default.
- W2914301545 cites W2076361525 @default.
- W2914301545 cites W2079418607 @default.
- W2914301545 cites W2080815766 @default.
- W2914301545 cites W2082890018 @default.
- W2914301545 cites W2083748423 @default.
- W2914301545 cites W2087144130 @default.
- W2914301545 cites W2087368694 @default.
- W2914301545 cites W2097098907 @default.
- W2914301545 cites W2099039895 @default.
- W2914301545 cites W2099214157 @default.
- W2914301545 cites W2102578857 @default.
- W2914301545 cites W2104904748 @default.
- W2914301545 cites W2105009484 @default.
- W2914301545 cites W2108578752 @default.
- W2914301545 cites W2109491705 @default.