Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914302014> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2914302014 endingPage "726" @default.
- W2914302014 startingPage "722" @default.
- W2914302014 abstract "Objective: to evaluate the efficacy and safety of a selective phosphodiesterase type 4 inhibitor in patients with psoriasis and psoriatic arthritis (PsA). Subjects and methods. An open uncontrolled study was conducted, which enrolled 20 patients (12 men, 8 women); their mean age was 39.2±14.3 years, the mean duration of psoriasis and PsA was 20.2±12.2 and 10.4±10.2 years, respectively. All the patients included in the study had previously received phototherapy, systemic drugs (methotrexate, aromatic retinoids) with an insufficient effect. Apremilast was administered according to the standard regimen: dose titration during the first 5 days, then 30-mg tablets twice daily for 26 weeks. The efficiency of the therapy was evaluated from changes in PASI, BSA, and sPGA and according to the American College of Rheumatology (ACR) criteria at 14 and 26 weeks and from those in DAS28 at 26 week. Results and discussion. There were 50 and 75% decreases in PASI respectively in 12 (60%) and 5 (25%) patients, at week 14 of therapy and in 14 (70%) and 7 (35%) patients at week 26. Fourteen (81.2%) patients achieved 20% ACR improvement at week 14. DAS28 decreased on an average by 1.8 at week 26. Adverse events (severe headache, tachycardia) were observed in two patients who were excluded from the study. Conclusion. Apremilast is an effective and safe agent for the treatment of psoriasis and PsA in patients who have received another systemic therapy proven to be ineffective or they tolerated the latter poorly." @default.
- W2914302014 created "2019-02-21" @default.
- W2914302014 creator A5008482641 @default.
- W2914302014 creator A5020595851 @default.
- W2914302014 creator A5063445087 @default.
- W2914302014 date "2019-01-22" @default.
- W2914302014 modified "2023-10-05" @default.
- W2914302014 title "New opportunities in the treatment of psoriasis and psoriatic arthritis" @default.
- W2914302014 cites W1919283206 @default.
- W2914302014 cites W2083180635 @default.
- W2914302014 cites W2139788459 @default.
- W2914302014 cites W2266045195 @default.
- W2914302014 cites W2283652574 @default.
- W2914302014 cites W2327265770 @default.
- W2914302014 cites W2761260370 @default.
- W2914302014 cites W2795686103 @default.
- W2914302014 cites W2799813944 @default.
- W2914302014 cites W2806358686 @default.
- W2914302014 cites W2886187951 @default.
- W2914302014 cites W2889126816 @default.
- W2914302014 doi "https://doi.org/10.14412/1995-4484-2018-722-726" @default.
- W2914302014 hasPublicationYear "2019" @default.
- W2914302014 type Work @default.
- W2914302014 sameAs 2914302014 @default.
- W2914302014 citedByCount "5" @default.
- W2914302014 countsByYear W29143020142019 @default.
- W2914302014 countsByYear W29143020142020 @default.
- W2914302014 countsByYear W29143020142021 @default.
- W2914302014 countsByYear W29143020142023 @default.
- W2914302014 crossrefType "journal-article" @default.
- W2914302014 hasAuthorship W2914302014A5008482641 @default.
- W2914302014 hasAuthorship W2914302014A5020595851 @default.
- W2914302014 hasAuthorship W2914302014A5063445087 @default.
- W2914302014 hasBestOaLocation W29143020141 @default.
- W2914302014 hasConcept C126322002 @default.
- W2914302014 hasConcept C16005928 @default.
- W2914302014 hasConcept C197934379 @default.
- W2914302014 hasConcept C198451711 @default.
- W2914302014 hasConcept C2776260265 @default.
- W2914302014 hasConcept C2780564577 @default.
- W2914302014 hasConcept C2781059491 @default.
- W2914302014 hasConcept C2781413609 @default.
- W2914302014 hasConcept C2781427535 @default.
- W2914302014 hasConcept C71924100 @default.
- W2914302014 hasConceptScore W2914302014C126322002 @default.
- W2914302014 hasConceptScore W2914302014C16005928 @default.
- W2914302014 hasConceptScore W2914302014C197934379 @default.
- W2914302014 hasConceptScore W2914302014C198451711 @default.
- W2914302014 hasConceptScore W2914302014C2776260265 @default.
- W2914302014 hasConceptScore W2914302014C2780564577 @default.
- W2914302014 hasConceptScore W2914302014C2781059491 @default.
- W2914302014 hasConceptScore W2914302014C2781413609 @default.
- W2914302014 hasConceptScore W2914302014C2781427535 @default.
- W2914302014 hasConceptScore W2914302014C71924100 @default.
- W2914302014 hasIssue "6" @default.
- W2914302014 hasLocation W29143020141 @default.
- W2914302014 hasOpenAccess W2914302014 @default.
- W2914302014 hasPrimaryLocation W29143020141 @default.
- W2914302014 hasRelatedWork W2313199171 @default.
- W2914302014 hasRelatedWork W2561265375 @default.
- W2914302014 hasRelatedWork W2790463647 @default.
- W2914302014 hasRelatedWork W2891943640 @default.
- W2914302014 hasRelatedWork W2991200093 @default.
- W2914302014 hasRelatedWork W3108657795 @default.
- W2914302014 hasRelatedWork W3195838575 @default.
- W2914302014 hasRelatedWork W3200801096 @default.
- W2914302014 hasRelatedWork W4200567964 @default.
- W2914302014 hasRelatedWork W4246299568 @default.
- W2914302014 hasVolume "56" @default.
- W2914302014 isParatext "false" @default.
- W2914302014 isRetracted "false" @default.
- W2914302014 magId "2914302014" @default.
- W2914302014 workType "article" @default.