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- W2914320855 abstract "Abstract The article describes diabetes mellitus which is a chronic disease resulting from a complex inheritance-environment interaction. Vitamin D has a role in the type 2 diabetes mellitus (T2DM) pathogenesis through the relationship between the deficiency of vitamin D and resistance of insulin. The main objective of the article is to analyze the correlation of the receptor's vitamin D FOKI gene polymorphism with T2DM in a sample of the Iraqi population. One-hundred-ninety-five Iraqi individuals (94 T2DM and 101 controls) were enrolled in this case-control study. FOKI SNP of the VDR gene was genotyped by using Tetra primer ARMS-PCR. The homozygous genotype CC and the allele C were correlated with significant risk of T2DM (OR=2.7, 95% CI; 1.5–4.8, p=0.0009) and (OR= 1.8, 95% CI; 1.17–2.9, p=0.006) respectively. FOKI polymorphism has causative effects on the risk for T2DM and Tetra-primer ARMS-PCR method was simple, economic and could be useful to genotype VDR gene polymorphisms in routine clinical and resource-limited settings." @default.
- W2914320855 created "2019-02-21" @default.
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- W2914320855 date "2019-06-01" @default.
- W2914320855 modified "2023-09-27" @default.
- W2914320855 title "Genotyping of vitamin D receptor FOKI polymorphism as a predictor for type 2 diabetes mellitus by a tetra primer-ARMS-PCR assay" @default.
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- W2914320855 doi "https://doi.org/10.1016/j.genrep.2019.01.003" @default.
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