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- W2914329121 abstract "The gut microbiota plays a key role in cholesterol metabolism, mainly through the reduction of cholesterol to coprostanol. The latter sterol exhibits distinct physicochemical properties linked to its limited absorption in the gut. Few bacteria were reported to reduce cholesterol into coprostanol. Three microbial pathways of coprostanol production were described based on the analysis of reaction intermediates. However, these metabolic pathways and their associated genes remain poorly studied. In this review, we shed light on the microbial metabolic pathways related to coprostanol synthesis. Moreover, we highlight current strategies and future directions to better characterize these microbial enzymes and pathways." @default.
- W2914329121 created "2019-02-21" @default.
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- W2914329121 date "2019-02-08" @default.
- W2914329121 modified "2023-09-26" @default.
- W2914329121 title "Microbial Reduction of Cholesterol to Coprostanol: An Old Concept and New Insights" @default.
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- W2914329121 doi "https://doi.org/10.3390/catal9020167" @default.
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