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• W2914352015 abstract "Central nervous system infections are frequently devastating and can lead to significant morbidity and mortality. Although the brain possesses several defence mechanisms (e.g. intact cranium, blood–brain barrier) to prevent infection, once microorganisms reach the central nervous system, host defence mechanisms are inadequate to control the infection. Antimicrobial therapy is also limited by the poor penetration of many agents into the central nervous system. This chapter reviews meningitis, brain abscess, subdural empyema, epidural abscess, encephalitis, postpolio syndrome and Creutzfeldt–Jakob disease, stressing recent developments in diagnosis and therapy and the use of adjunctive treatment strategies that have been shown to improve outcome in patients with some of these devastating infections." @default.
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• W2914352015 date "2012-03-12" @default.
• W2914352015 modified "2023-10-13" @default.
• W2914352015 title "Infections of the Central Nervous System" @default.
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• W2914352015 doi "https://doi.org/10.1002/9781119952930.ch117" @default.
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