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• W2914362188 abstract "Embedding palladium ahead of time Palladium-catalyzed cross-coupling is one of the most widely applied reaction classes in pharmaceutical research. The metal is adept at connecting aromatic rings to one another or to nitrogen centers. However, functional complexity can obstruct the reaction, necessitating laborious ligand optimization. Uehling et al. mitigated this problem by isolating the stable product of palladium's reaction with a complex aryl halide ahead of time. Subjecting these compounds to downstream coupling reactions substantially improved yields. Science , this issue p. 405" @default.
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• W2914362188 date "2019-01-25" @default.
• W2914362188 modified "2023-10-14" @default.
• W2914362188 title "Pharmaceutical diversification via palladium oxidative addition complexes" @default.
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• W2914362188 doi "https://doi.org/10.1126/science.aac6153" @default.
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