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- W2914363434 endingPage "359" @default.
- W2914363434 startingPage "344" @default.
- W2914363434 abstract "Several key attributes of zebrafish make them an ideal model system for the discovery and development of regeneration promoting therapeutics; most notably their robust capacity for self-repair which extends to the central nervous system. Further, by enabling large-scale drug discovery directly in living vertebrate disease models, zebrafish circumvent critical bottlenecks which have driven drug development costs up. This review summarizes currently available zebrafish phenotypic screening platforms, HTS-ready neurodegenerative disease modeling strategies, zebrafish small molecule screens which have succeeded in identifying regeneration promoting compounds and explores how intravital imaging in zebrafish can facilitate comprehensive analysis of nanocarrier biodistribution and pharmacokinetics. Finally, we discuss the benefits and challenges attending the combination of zebrafish and nanoparticle-based drug optimization, highlighting inspiring proof-of-concept studies and looking toward implementation across the drug development community." @default.
- W2914363434 created "2019-02-21" @default.
- W2914363434 creator A5018102327 @default.
- W2914363434 creator A5018121392 @default.
- W2914363434 creator A5024432514 @default.
- W2914363434 date "2019-08-01" @default.
- W2914363434 modified "2023-10-12" @default.
- W2914363434 title "Let's get small (and smaller): Combining zebrafish and nanomedicine to advance neuroregenerative therapeutics" @default.
- W2914363434 cites W1528028656 @default.
- W2914363434 cites W1534619511 @default.
- W2914363434 cites W1615535881 @default.
- W2914363434 cites W1772047752 @default.
- W2914363434 cites W1796054280 @default.
- W2914363434 cites W1860885924 @default.
- W2914363434 cites W1964814516 @default.
- W2914363434 cites W1966952812 @default.
- W2914363434 cites W1967133409 @default.
- W2914363434 cites W1967695541 @default.
- W2914363434 cites W1974339266 @default.
- W2914363434 cites W1975362267 @default.
- W2914363434 cites W1975781078 @default.
- W2914363434 cites W1976391205 @default.
- W2914363434 cites W1976404547 @default.
- W2914363434 cites W1979357501 @default.
- W2914363434 cites W1979457930 @default.
- W2914363434 cites W1980230824 @default.
- W2914363434 cites W1980758898 @default.
- W2914363434 cites W1981066521 @default.
- W2914363434 cites W1981239255 @default.
- W2914363434 cites W1983109395 @default.
- W2914363434 cites W1984439372 @default.
- W2914363434 cites W1985835614 @default.
- W2914363434 cites W1986366086 @default.
- W2914363434 cites W1992283047 @default.
- W2914363434 cites W1992663358 @default.
- W2914363434 cites W1993746164 @default.
- W2914363434 cites W1996387806 @default.
- W2914363434 cites W1999600164 @default.
- W2914363434 cites W2001728487 @default.
- W2914363434 cites W2002059065 @default.
- W2914363434 cites W2005889545 @default.
- W2914363434 cites W2009288184 @default.
- W2914363434 cites W2009766076 @default.
- W2914363434 cites W2014843809 @default.
- W2914363434 cites W2017429680 @default.
- W2914363434 cites W2018425216 @default.
- W2914363434 cites W2018956577 @default.
- W2914363434 cites W2020607530 @default.
- W2914363434 cites W2022288348 @default.
- W2914363434 cites W2022564018 @default.
- W2914363434 cites W2025188006 @default.
- W2914363434 cites W2026858401 @default.
- W2914363434 cites W2028117650 @default.
- W2914363434 cites W2029879701 @default.
- W2914363434 cites W2030148532 @default.
- W2914363434 cites W2030977705 @default.
- W2914363434 cites W2032417286 @default.
- W2914363434 cites W2034064528 @default.
- W2914363434 cites W2037306331 @default.
- W2914363434 cites W2037798456 @default.
- W2914363434 cites W2039251135 @default.
- W2914363434 cites W2039331751 @default.
- W2914363434 cites W2039525732 @default.
- W2914363434 cites W2039568446 @default.
- W2914363434 cites W2040243871 @default.
- W2914363434 cites W2044971968 @default.
- W2914363434 cites W2046340162 @default.
- W2914363434 cites W2048502950 @default.
- W2914363434 cites W2049309227 @default.
- W2914363434 cites W2050376918 @default.
- W2914363434 cites W2050702451 @default.
- W2914363434 cites W2052877884 @default.
- W2914363434 cites W2053374578 @default.
- W2914363434 cites W2056109753 @default.
- W2914363434 cites W2058207889 @default.
- W2914363434 cites W2060591168 @default.
- W2914363434 cites W2062605235 @default.
- W2914363434 cites W2062642362 @default.
- W2914363434 cites W2062853793 @default.
- W2914363434 cites W2062910860 @default.
- W2914363434 cites W2070302990 @default.
- W2914363434 cites W2070381140 @default.
- W2914363434 cites W2072121792 @default.
- W2914363434 cites W2072316722 @default.
- W2914363434 cites W2074945181 @default.
- W2914363434 cites W2076237697 @default.
- W2914363434 cites W2076664843 @default.
- W2914363434 cites W2078137220 @default.
- W2914363434 cites W2079258400 @default.
- W2914363434 cites W2081095452 @default.
- W2914363434 cites W2083404959 @default.
- W2914363434 cites W2083714850 @default.
- W2914363434 cites W2087375863 @default.
- W2914363434 cites W2089656194 @default.
- W2914363434 cites W2090730054 @default.
- W2914363434 cites W2092473589 @default.
- W2914363434 cites W2095498253 @default.
- W2914363434 cites W2097212244 @default.