FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914369563> ?p ?o ?g. }

• W2914369563 endingPage "267" @default.
• W2914369563 startingPage "259" @default.
• W2914369563 abstract "is commonly used for children undergoing hypospadias repair. However, the safety of caudal block for hypospadias repair in children is controversial in terms of surgical complications such as urethrocutaneous fistula and glans dehiscence. We sought to perform a meta-analysis to estimate the analgesic efficacy and relative complications of caudal block for hypospadias repair in children.We identified comparative studies of caudal block versus peripheral nerve block or no caudal block; studies were published or presented through 1 January 2018, and reports of analgesic efficacy or surgical complications of hypospadias repair in children were identified. Peripheral nerve block includes dorsal nerve penile block and pudendal nerve block. Data were abstracted from studies comparing caudal block with peripheral nerve block or no caudal block; original source data were used when available. We prespecified separate assessments of randomized controlled trials (RCTs) and observational studies given the inherent differences between types of study designs. Data from 298 patients in four RCTs and from 1726 patients in seven observational studies were included. RCT and observational data were analyzed separately.In RCTs, caudal blocks (compared with peripheral nerve blocks) showed no detectable differences in terms of need for additional analgesia within 24 hours after the surgery (OR 10.49; 95% CI 0.32 to 343.24; p=0.19), but limited data showed lower pain scores 24 hours after the surgery (standardized mean difference (SMD) 1.57; 95% CI 0.29 to 2.84; p=0.02), a significantly shorter duration of analgesia (SMD -3.33; 95% CI -4.18 to -2.48; p<0.0001) and analgesics consumption. No significant differences were observed in terms of postoperative nausea and vomiting (OR 3.08; 95% CI 0.12 to 77.80; p=0.50) or motor weakness (OR 0.01; 95% CI -0.03 to 0.05; p=0.56). Only one randomized study showed that caudal blocks (compared with peripheral nerve blocks) were associated with detectable differences in urethrocutaneous fistula rate (OR 25.27; 95% CI 1.37 to 465.01; p=0.03) and parental satisfaction rate (OR 0.07; 95% CI 0.02 to 0.21; p<0.00001). In observational studies, caudal block was not associated with surgical complications in all types of primary hypospadias repair (OR 1.83; 95% CI 0.80 to 4.16; p=0.15). To adjust for confounding factors and to eliminate potential selection bias involving caudal block indication, we performed subgroup analysis including only patients with distal hypospadias. This analysis revealed similar complication rates in children who received a caudal block and in children not receiving caudal block (OR 1.02; 95% CI, 0.39 to 2.65; p=0.96). This result further confirmed that caudal block was not a risk factor for surgical complications in hypospadias repair. The direction of outcomes in all the other subgroup analyses did not change, suggesting stability of our results.In RCTs, only limited data showed peripheral nerve blocks providing better analgesic quality compared with caudal blocks. In real-world non-randomized observational studies with greater number of patients (but with admitted the potential for a presence of selection bias and residual confounders), caudal blocks were not associated with postoperative complications including urethrocutaneous fistula and glans dehiscence." @default.
• W2914369563 created "2019-02-21" @default.
• W2914369563 creator A5008191957 @default.
• W2914369563 creator A5008574559 @default.
• W2914369563 creator A5043861530 @default.
• W2914369563 creator A5043885363 @default.
• W2914369563 creator A5064602921 @default.
• W2914369563 creator A5073706757 @default.
• W2914369563 date "2019-01-30" @default.
• W2914369563 modified "2023-10-03" @default.
• W2914369563 title "Analgesic efficacy and impact of caudal block on surgical complications of hypospadias repair: a systematic review and meta-analysis" @default.
• W2914369563 cites W1104940987 @default.
• W2914369563 cites W1607945995 @default.
• W2914369563 cites W1904231753 @default.
• W2914369563 cites W1947330737 @default.
• W2914369563 cites W1966127150 @default.
• W2914369563 cites W1983160229 @default.
• W2914369563 cites W19849081 @default.
• W2914369563 cites W2025768546 @default.
• W2914369563 cites W2049445471 @default.
• W2914369563 cites W2063303331 @default.
• W2914369563 cites W2063312007 @default.
• W2914369563 cites W2069332995 @default.
• W2914369563 cites W2078448572 @default.
• W2914369563 cites W2098923148 @default.
• W2914369563 cites W2107522114 @default.
• W2914369563 cites W2129655601 @default.
• W2914369563 cites W2148560305 @default.
• W2914369563 cites W2158505111 @default.
• W2914369563 cites W2163425952 @default.
• W2914369563 cites W2263226732 @default.
• W2914369563 cites W2346265944 @default.
• W2914369563 cites W2409778386 @default.
• W2914369563 cites W2511920006 @default.
• W2914369563 cites W2531269403 @default.
• W2914369563 cites W2545157195 @default.
• W2914369563 cites W2545439893 @default.
• W2914369563 cites W2593016975 @default.
• W2914369563 cites W2602264707 @default.
• W2914369563 cites W2742315192 @default.
• W2914369563 cites W2743653855 @default.
• W2914369563 cites W2767458046 @default.
• W2914369563 cites W2768161012 @default.
• W2914369563 cites W2792450518 @default.
• W2914369563 cites W4252454340 @default.
• W2914369563 doi "https://doi.org/10.1136/rapm-2018-000022" @default.
• W2914369563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700621" @default.
• W2914369563 hasPublicationYear "2019" @default.
• W2914369563 type Work @default.
• W2914369563 sameAs 2914369563 @default.
• W2914369563 citedByCount "27" @default.
• W2914369563 countsByYear W29143695632019 @default.
• W2914369563 countsByYear W29143695632020 @default.
• W2914369563 countsByYear W29143695632021 @default.
• W2914369563 countsByYear W29143695632022 @default.
• W2914369563 countsByYear W29143695632023 @default.
• W2914369563 crossrefType "journal-article" @default.
• W2914369563 hasAuthorship W2914369563A5008191957 @default.
• W2914369563 hasAuthorship W2914369563A5008574559 @default.
• W2914369563 hasAuthorship W2914369563A5043861530 @default.
• W2914369563 hasAuthorship W2914369563A5043885363 @default.
• W2914369563 hasAuthorship W2914369563A5064602921 @default.
• W2914369563 hasAuthorship W2914369563A5073706757 @default.
• W2914369563 hasConcept C126322002 @default.
• W2914369563 hasConcept C141071460 @default.
• W2914369563 hasConcept C168563851 @default.
• W2914369563 hasConcept C23131810 @default.
• W2914369563 hasConcept C2777050469 @default.
• W2914369563 hasConcept C2777197265 @default.
• W2914369563 hasConcept C2777786686 @default.
• W2914369563 hasConcept C2777990738 @default.
• W2914369563 hasConcept C2780682423 @default.
• W2914369563 hasConcept C2780820201 @default.
• W2914369563 hasConcept C42219234 @default.
• W2914369563 hasConcept C71924100 @default.
• W2914369563 hasConcept C95190672 @default.
• W2914369563 hasConceptScore W2914369563C126322002 @default.
• W2914369563 hasConceptScore W2914369563C141071460 @default.
• W2914369563 hasConceptScore W2914369563C168563851 @default.
• W2914369563 hasConceptScore W2914369563C23131810 @default.
• W2914369563 hasConceptScore W2914369563C2777050469 @default.
• W2914369563 hasConceptScore W2914369563C2777197265 @default.
• W2914369563 hasConceptScore W2914369563C2777786686 @default.
• W2914369563 hasConceptScore W2914369563C2777990738 @default.
• W2914369563 hasConceptScore W2914369563C2780682423 @default.
• W2914369563 hasConceptScore W2914369563C2780820201 @default.
• W2914369563 hasConceptScore W2914369563C42219234 @default.
• W2914369563 hasConceptScore W2914369563C71924100 @default.
• W2914369563 hasConceptScore W2914369563C95190672 @default.
• W2914369563 hasIssue "2" @default.
• W2914369563 hasLocation W29143695631 @default.
• W2914369563 hasLocation W29143695632 @default.
• W2914369563 hasOpenAccess W2914369563 @default.
• W2914369563 hasPrimaryLocation W29143695631 @default.
• W2914369563 hasRelatedWork W1544205361 @default.
• W2914369563 hasRelatedWork W1979143377 @default.
• W2914369563 hasRelatedWork W2034971981 @default.
• W2914369563 hasRelatedWork W2070478571 @default.

• next