FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914371185> ?p ?o ?g. }

• W2914371185 endingPage "706" @default.
• W2914371185 startingPage "696" @default.
• W2914371185 abstract "Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumour associated with poor 5-year survival. We aimed to determine factors which differentiate short and long-term survivors and identify a prognostic biomarker.Over a ten-year period, patients with resected PDAC who developed disease recurrence within 12 months (Group I) and those who had no disease recurrence for 24 months (Group II) were identified. Clinicopathological data was analysed. Ion Torrent high-throughput sequencing on DNA extracted from FFPE tumour samples was used to identify mutations. Additionally, peripheral blood samples were analysed for variants in cell-free DNA, circulating tumour cells (CTCs), and microRNAs.Multivariable analysis of clinicopathological factors showed that a positive medial resection margin was significantly associated with short disease-free survival (p = 0.007). Group I patients (n = 21) had a higher frequency of the KRAS mutant mean variant allele (16.93% ± 11.04) compared to those in Group II (n = 13; 7.55% ± 5.76, p = 0.0078). Group I patients also trended towards having a KRAS c.35G>A p.Gly12Asp mutation in addition to variants in other genes, such as TP53, CDKN2A, and SMAD4. Mutational status of cell-free DNA, and number of CTCs, was not found to be useful in this study. A circulating miRNA (hsa-miR-548ah-5p) was found to be significantly differentially expressed.Medial resection margin status and the frequency of KRAS mutation in the tumour tissue are independent prognostic indicators for resectable PDAC. Circulating miRNA hsa-miR-548ah-5p has the potential to be used as a prognostic biomarker." @default.
• W2914371185 created "2019-02-21" @default.
• W2914371185 creator A5002660666 @default.
• W2914371185 creator A5013998402 @default.
• W2914371185 creator A5025082838 @default.
• W2914371185 creator A5031000713 @default.
• W2914371185 creator A5042431725 @default.
• W2914371185 creator A5053323102 @default.
• W2914371185 creator A5063569331 @default.
• W2914371185 creator A5069234120 @default.
• W2914371185 creator A5078407406 @default.
• W2914371185 creator A5078706966 @default.
• W2914371185 date "2019-01-22" @default.
• W2914371185 modified "2023-10-14" @default.
• W2914371185 title "Can we predict long-term survival in resectable pancreatic ductal adenocarcinoma?" @default.
• W2914371185 cites W1507991646 @default.
• W2914371185 cites W171510207 @default.
• W2914371185 cites W1945319061 @default.
• W2914371185 cites W1964763549 @default.
• W2914371185 cites W1971589201 @default.
• W2914371185 cites W1981989535 @default.
• W2914371185 cites W1982078244 @default.
• W2914371185 cites W1984935494 @default.
• W2914371185 cites W1987453295 @default.
• W2914371185 cites W1989511082 @default.
• W2914371185 cites W1993147908 @default.
• W2914371185 cites W1998036846 @default.
• W2914371185 cites W1998516681 @default.
• W2914371185 cites W2006022749 @default.
• W2914371185 cites W2009415598 @default.
• W2914371185 cites W2016680388 @default.
• W2914371185 cites W2029817922 @default.
• W2914371185 cites W2034893372 @default.
• W2914371185 cites W2040693082 @default.
• W2914371185 cites W2044548139 @default.
• W2914371185 cites W2048038826 @default.
• W2914371185 cites W2049488969 @default.
• W2914371185 cites W2056494524 @default.
• W2914371185 cites W2079934168 @default.
• W2914371185 cites W2081775759 @default.
• W2914371185 cites W2084400227 @default.
• W2914371185 cites W2088158925 @default.
• W2914371185 cites W2088832018 @default.
• W2914371185 cites W2096998881 @default.
• W2914371185 cites W2104164610 @default.
• W2914371185 cites W2106124267 @default.
• W2914371185 cites W2110666579 @default.
• W2914371185 cites W2118797060 @default.
• W2914371185 cites W2129197203 @default.
• W2914371185 cites W2129204015 @default.
• W2914371185 cites W2131596261 @default.
• W2914371185 cites W2132388337 @default.
• W2914371185 cites W2137649483 @default.
• W2914371185 cites W2138155367 @default.
• W2914371185 cites W2139923592 @default.
• W2914371185 cites W2144038313 @default.
• W2914371185 cites W2145145022 @default.
• W2914371185 cites W2162502060 @default.
• W2914371185 cites W2317401966 @default.
• W2914371185 cites W2384499297 @default.
• W2914371185 cites W2404947885 @default.
• W2914371185 cites W2542863264 @default.
• W2914371185 cites W2783074748 @default.
• W2914371185 cites W2801588121 @default.
• W2914371185 cites W2890048723 @default.
• W2914371185 cites W2904348480 @default.
• W2914371185 doi "https://doi.org/10.18632/oncotarget.26511" @default.
• W2914371185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6366827" @default.
• W2914371185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30774772" @default.
• W2914371185 hasPublicationYear "2019" @default.
• W2914371185 type Work @default.
• W2914371185 sameAs 2914371185 @default.
• W2914371185 citedByCount "5" @default.
• W2914371185 countsByYear W29143711852021 @default.
• W2914371185 countsByYear W29143711852022 @default.
• W2914371185 countsByYear W29143711852023 @default.
• W2914371185 crossrefType "journal-article" @default.
• W2914371185 hasAuthorship W2914371185A5002660666 @default.
• W2914371185 hasAuthorship W2914371185A5013998402 @default.
• W2914371185 hasAuthorship W2914371185A5025082838 @default.
• W2914371185 hasAuthorship W2914371185A5031000713 @default.
• W2914371185 hasAuthorship W2914371185A5042431725 @default.
• W2914371185 hasAuthorship W2914371185A5053323102 @default.
• W2914371185 hasAuthorship W2914371185A5063569331 @default.
• W2914371185 hasAuthorship W2914371185A5069234120 @default.
• W2914371185 hasAuthorship W2914371185A5078407406 @default.
• W2914371185 hasAuthorship W2914371185A5078706966 @default.
• W2914371185 hasBestOaLocation W29143711851 @default.
• W2914371185 hasConcept C121608353 @default.
• W2914371185 hasConcept C126322002 @default.
• W2914371185 hasConcept C141071460 @default.
• W2914371185 hasConcept C142724271 @default.
• W2914371185 hasConcept C143998085 @default.
• W2914371185 hasConcept C159110652 @default.
• W2914371185 hasConcept C2778132481 @default.
• W2914371185 hasConcept C2780265364 @default.
• W2914371185 hasConcept C2781182431 @default.
• W2914371185 hasConcept C2781187634 @default.

• next