Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914377961> ?p ?o ?g. }
- W2914377961 abstract "Cardiomyopathies, heart failure, and arrhythmias or conduction blockages impact millions of patients worldwide and are associated with marked increases in sudden cardiac death, decline in the quality of life, and the induction of secondary pathologies. These pathologies stem from dysfunction in the contractile or conductive properties of the cardiomyocyte, which as a result is a focus of fundamental investigation, drug discovery and therapeutic development, and tissue engineering. All of these foci require in vitro myocardial models and experimental techniques to probe the physiological functions of the cardiomyocyte. In this review, we provide a detailed exploration of different cell models, disease modeling strategies, and tissue constructs used from basic to translational research. Furthermore, we highlight recent advancements in imaging, electrophysiology, metabolic measurements, and mechanical and contractile characterization modalities that are advancing our understanding of cardiomyocyte physiology. With this review, we aim to both provide a biological framework for engineers contributing to the field and demonstrate the technical basis and limitations underlying physiological measurement modalities for biologists attempting to take advantage of these state-of-the-art techniques." @default.
- W2914377961 created "2019-02-21" @default.
- W2914377961 creator A5017068131 @default.
- W2914377961 creator A5021102152 @default.
- W2914377961 creator A5035000458 @default.
- W2914377961 creator A5039974810 @default.
- W2914377961 creator A5045991393 @default.
- W2914377961 date "2019-02-05" @default.
- W2914377961 modified "2023-10-12" @default.
- W2914377961 title "Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development <i>in vitro</i>" @default.
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