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• W2914381831 abstract "Abstract The majority of oligodendrocytes in the neocortex originate from neural progenitors that reside in the dorsal forebrain. We recently showed that Sonic Hedgehog (Shh) signaling in these dorsal progenitors is required to produce normal numbers of neocortical oligodendrocytes during embryonic development. Conditional deletion of the Shh signaling effector, Smo , in dorsal progenitors caused a dramatic reduction in oligodendrocyte numbers in the embryonic neocortex. In the current study, we show that the depleted oligodendrocyte lineage in Smo conditional mutants is able to recover to control numbers over time. This eventual recovery is achieved in part by expansion of the ventrally-derived wild-type lineage that normally makes up a minority of the total oligodendrocyte population. However, we find that the remaining dorsally-derived mutant cells also increase in numbers over time to contribute equally to the recovery of the total population. Additionally, we found that the ways in which the dorsal and ventral sources cooperate to achieve recovery is different for distinct subclasses of oligodendrocyte-lineage cells. Oligodendrocyte precursor cells (OPCs) in the neocortical white matter recover completely by expansion of the remaining dorsally-derived Smo mutant cells. On the other hand, mature oligodendrocytes in the white and gray matter recover through an equal contribution from dorsal mutant and ventral wild-type lineages. Interestingly, the only population that did not make a full recovery was OPCs in the gray matter. We find that gray matter OPCs are less proliferative in Smo cKO mutants compared to controls, which may explain their inability to fully recover. These studies shed light on the nature of competition and cooperation between dorsal and ventral sources of oligodendrocytes in the developing neocortex. Furthermore, our data point towards differential use of Shh signaling in the development of distinct subclasses of the oligodendrocyte lineage." @default.
• W2914381831 created "2019-02-21" @default.
• W2914381831 creator A5001928112 @default.
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• W2914381831 date "2019-02-12" @default.
• W2914381831 modified "2023-10-16" @default.
• W2914381831 title "Loss of Shh signaling in the neocortex reveals heterogeneous cell recovery responses from distinct oligodendrocyte populations" @default.
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• W2914381831 doi "https://doi.org/10.1101/547968" @default.
• W2914381831 hasPublicationYear "2019" @default.
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