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• W2914394986 endingPage "256" @default.
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• W2914394986 abstract "Current treatments for TMDs lack long-term efficacy and are palliative, motivating tissue-engineering for repair or replacement of the injured or ailing tissues in the TMJ, such as the disc. Scaffold-based or scaffold-free approaches, cell sources, biochemical stimuli, and mechanical stimuli are all elements of the tissue-engineering process that need to be considered to tailor TMJ disc construct properties. Large animals can serve as models of human TMDs; orthotopic implantation in large animal models is a necessary translational step. The first successful orthotopic study of the TMJ disc in a large animal model has primed the field for translation of tissue-engineered constructs; however, there are still numerous hurdles prior to human clinical trials. The temporomandibular joint (TMJ) disc, a fibrocartilaginous structure between the mandible and temporal bone, is implicated in temporomandibular disorders (TMDs). TMDs symptomatically affect approximately 25% of the population, of which 70% have internal derangement of the disc. Treatments lack efficiency, motivating novel therapies, including tissue-engineering toward TMJ disc regeneration. Recent developments in scaffold-based or scaffold-free approaches, cell sources, and biochemical and mechanical stimulation have resulted in constructs exhibiting native tissue mechanics. Safety and efficacy of tissue-engineered implants have shown promising results in orthotopic animal studies. However, many hurdles need to be overcome in tissue-engineering approaches, and clinical and regulatory pathways. Future studies present an opportunity for clinicians and researchers to work together toward safe and effective clinical trials. The temporomandibular joint (TMJ) disc, a fibrocartilaginous structure between the mandible and temporal bone, is implicated in temporomandibular disorders (TMDs). TMDs symptomatically affect approximately 25% of the population, of which 70% have internal derangement of the disc. Treatments lack efficiency, motivating novel therapies, including tissue-engineering toward TMJ disc regeneration. Recent developments in scaffold-based or scaffold-free approaches, cell sources, and biochemical and mechanical stimulation have resulted in constructs exhibiting native tissue mechanics. Safety and efficacy of tissue-engineered implants have shown promising results in orthotopic animal studies. However, many hurdles need to be overcome in tissue-engineering approaches, and clinical and regulatory pathways. Future studies present an opportunity for clinicians and researchers to work together toward safe and effective clinical trials. joint functioning in both rotation and translation. misalignment or displacement of the TMJ disc from a normal anatomical position. mechanical grinding of food into smaller pieces by teeth. slowly progressing joint disease characterized by degenerative changes in the cartilage and subchondral bone; presents through wear of the cartilage or underlying bone and presence of osteophytes; commonly affects large diarthrodial joints such as the knee, but also joints such as the TMJ. semiquantitative measure of severity of OA based on histomorphological analysis of cartilage, underlying bone, and degenerative marks such as osteophytes; a higher number indicates increased degeneration; standardized by various groups including the Osteoarthritis Research Society International (OARSI) and the International Cartilage Regeneration and Joint Preservation Society (ICRS). material property defining the stiffness of a material when deformed by uniaxial tension or compression; measured as the ratio of stress (force per unit area) to strain (change in length divided by original length)." @default.
• W2914394986 created "2019-02-21" @default.
• W2914394986 creator A5001646095 @default.
• W2914394986 creator A5028617073 @default.
• W2914394986 creator A5082324061 @default.
• W2914394986 date "2019-03-01" @default.
• W2914394986 modified "2023-10-12" @default.
• W2914394986 title "Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc" @default.
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