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- W2914406467 endingPage "581" @default.
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- W2914406467 abstract "This review discusses the profound connection between microglia, neuroinflammation, and Alzheimer's disease (AD). Theories have been postulated, tested, and modified over several decades. The findings have further bolstered the belief that microglia-mediated inflammation is both a product and contributor to AD pathology and progression. Distinct microglia phenotypes and their function, microglial recognition and response to protein aggregates in AD, and the overall role of microglia in AD are areas that have received considerable research attention and yielded significant results. The following article provides a historical perspective of microglia, a detailed discussion of multiple microglia phenotypes including dark microglia, and a review of a number of areas where microglia intersect with AD and other pathological neurological processes. The overall breadth of important discoveries achieved in these areas significantly strengthens the hypothesis that neuroinflammation plays a key role in AD. Future determination of the exact mechanisms by which microglia respond to, and attempt to mitigate, protein aggregation in AD may lead to new therapeutic strategies." @default.
- W2914406467 created "2019-02-21" @default.
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- W2914406467 date "2019-03-27" @default.
- W2914406467 modified "2023-10-17" @default.
- W2914406467 title "Inflammatory mechanisms in neurodegeneration" @default.
- W2914406467 cites W1250647964 @default.
- W2914406467 cites W1456373634 @default.
- W2914406467 cites W1526023859 @default.
- W2914406467 cites W1538369257 @default.
- W2914406467 cites W1549447146 @default.
- W2914406467 cites W1589545251 @default.
- W2914406467 cites W1607135210 @default.
- W2914406467 cites W1613451007 @default.
- W2914406467 cites W1622777525 @default.
- W2914406467 cites W1677883125 @default.
- W2914406467 cites W1768493813 @default.
- W2914406467 cites W183710148 @default.
- W2914406467 cites W1851356616 @default.
- W2914406467 cites W1914782230 @default.
- W2914406467 cites W1922340941 @default.
- W2914406467 cites W1923107093 @default.
- W2914406467 cites W1928993351 @default.
- W2914406467 cites W1937826833 @default.
- W2914406467 cites W1955481428 @default.
- W2914406467 cites W1964041350 @default.
- W2914406467 cites W1964229968 @default.
- W2914406467 cites W1964506812 @default.
- W2914406467 cites W1966831629 @default.
- W2914406467 cites W1967674023 @default.
- W2914406467 cites W1968906927 @default.
- W2914406467 cites W1970739057 @default.
- W2914406467 cites W1973522628 @default.
- W2914406467 cites W1977896329 @default.
- W2914406467 cites W1978567629 @default.
- W2914406467 cites W1982506852 @default.
- W2914406467 cites W1986777598 @default.
- W2914406467 cites W1987327052 @default.
- W2914406467 cites W1987922097 @default.
- W2914406467 cites W1990478133 @default.
- W2914406467 cites W1990636293 @default.
- W2914406467 cites W1991805788 @default.
- W2914406467 cites W1992598058 @default.
- W2914406467 cites W1993780955 @default.
- W2914406467 cites W1993976394 @default.
- W2914406467 cites W1993993136 @default.
- W2914406467 cites W1996024251 @default.
- W2914406467 cites W1996935470 @default.
- W2914406467 cites W1999345400 @default.
- W2914406467 cites W1999499766 @default.
- W2914406467 cites W2000648304 @default.
- W2914406467 cites W2003362379 @default.
- W2914406467 cites W2003813921 @default.
- W2914406467 cites W2005611089 @default.
- W2914406467 cites W2005681172 @default.
- W2914406467 cites W2010441033 @default.
- W2914406467 cites W2010464023 @default.
- W2914406467 cites W2010472544 @default.
- W2914406467 cites W2011041653 @default.
- W2914406467 cites W2011248746 @default.
- W2914406467 cites W2015068992 @default.
- W2914406467 cites W2015426193 @default.
- W2914406467 cites W2016575029 @default.
- W2914406467 cites W2022055086 @default.
- W2914406467 cites W2026397702 @default.
- W2914406467 cites W2030452219 @default.
- W2914406467 cites W2033105784 @default.
- W2914406467 cites W2033998934 @default.
- W2914406467 cites W2035230591 @default.
- W2914406467 cites W2036131097 @default.
- W2914406467 cites W2036362108 @default.
- W2914406467 cites W2036599501 @default.
- W2914406467 cites W2037099926 @default.
- W2914406467 cites W2037798333 @default.
- W2914406467 cites W2038689279 @default.
- W2914406467 cites W2041355017 @default.
- W2914406467 cites W2042706422 @default.
- W2914406467 cites W2044090829 @default.
- W2914406467 cites W2045560271 @default.
- W2914406467 cites W2045720033 @default.
- W2914406467 cites W2045772297 @default.
- W2914406467 cites W2046454316 @default.
- W2914406467 cites W2047511834 @default.
- W2914406467 cites W2047964142 @default.
- W2914406467 cites W2051651977 @default.
- W2914406467 cites W2051776695 @default.
- W2914406467 cites W2052651471 @default.
- W2914406467 cites W2054388625 @default.
- W2914406467 cites W2057310829 @default.