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- W2914408009 abstract "Abstract Noninvasive brain stimulation (NIBS) has exceedingly become a major area of research in the last decade. Methods such as repetitive transcranial magnetic stimulation (rTMS), or transcranial direct current stimulation (tDCS), have been investigated as new paradigms in treatment in a variety of psychiatric and neurological disorders. In psychiatry, focus has been laid on NIBS treatment for major depression and other affective disorders. Several neurobiological mechanisms may explain the effects of NIBS. They all seem to mediate neuroplasticity which accounts for the long-lasting poststimulation effects of NIBS. Involved pathways consist of neurotransmitters such as dopamine, gamma aminobutyric acid and n-methyl- d -aspartic acid receptors, the brain-derived neurotrophic factor, or coding genes. Studies combining NIBS and electrophysiological or neuroimaging methods contributed to the better understanding of some basic mechanisms that may increase treatment response in the future, with promising results observed considering the functional connectivity of specific brain areas. Still, response to NIBS remains variable, which limits its clinical application to date. There is a great need to further increase the understanding of the underlying neurobiological mechanisms, clinical feasibility, and the efficacy of these techniques." @default.
- W2914408009 created "2019-02-21" @default.
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- W2914408009 date "2019-01-01" @default.
- W2914408009 modified "2023-09-25" @default.
- W2914408009 title "Novel Neuromodulatory Approaches for Depression: Neurobiological Mechanisms" @default.
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