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• W2914411933 endingPage "517" @default.
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• W2914411933 abstract "Many key cell processes require prior cell uptake of amino acids from the environment, which is facilitated by cell membrane amino acid transporters such as those of the L-type amino acid transporter (LAT) subfamily. Alterations in LAT subfamily amino acid transport are associated with several human diseases, including cancer, aminoacidurias, and neurodegenerative conditions. Therefore, from the perspective of human health, there is considerable interest in obtaining structural information about these transporter proteins. We recently solved the crystal structure of the first LAT transporter, the bacterial alanine-serine-cysteine exchanger of Carnobacterium sp AT7 (BasC). Here, we provide a complete functional characterization of detergent-purified, liposome-reconstituted BasC transporter to allow the extension of the structural insights into mechanistic understanding. BasC is a sodium- and proton-independent small neutral amino acid exchanger whose substrate and inhibitor selectivity are almost identical to those previously described for the human LAT subfamily member Asc-1. Additionally, we show that, like its human counterparts, this transporter has apparent affinity asymmetry for the intra- and extracellular substrate binding sites—a key feature in the physiological role played by these proteins. BasC is an excellent paradigm of human LAT transporters and will contribute to our understanding of the molecular mechanisms underlying substrate recognition and translocation at both sides of the plasma membrane." @default.
• W2914411933 created "2019-02-21" @default.
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• W2914411933 date "2019-01-29" @default.
• W2914411933 modified "2023-10-09" @default.
• W2914411933 title "Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7" @default.
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• W2914411933 doi "https://doi.org/10.1085/jgp.201812195" @default.
• W2914411933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6445583" @default.
• W2914411933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30696726" @default.
• W2914411933 hasPublicationYear "2019" @default.
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