Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914419657> ?p ?o ?g. }
- W2914419657 endingPage "526" @default.
- W2914419657 startingPage "522" @default.
- W2914419657 abstract "HER2 is the only validated predictive biomarker in gastro-oesophageal carcinoma (GOC). However, several factors, such as heterogeneity in protein expression, shortage of evaluable tumour tissue and need for quick target assessment, underline the usefulness of a pre-screening tool in order to anticipate HER2 status.Data from 723 consecutive GOC analysed for HER2 at four Italian Institutions were collected. HER2 positivity was defined as 3+ by immunohistochemistry (IHC) or 2+ with gene amplification by in situ hybridisation (ISH). A multivariate logistic regression model was built using data from 413 cases, whereas 310 patients served as validation cohort. C-index, visual inspection of the calibration plot, Brier score and Spiegelhalter z-test were used to assess the performance of the nomogram.HER2 positive rate was 17.4%. Four variables were retained after adjustment in the final model: grading, Lauren's histotype, pathologic material analysed (surgical specimen/biopsy) and site of tissue collection (primary tumour/metastases). Visual inspection of the calibration plot revealed a very good overlap between predicted and observed probabilities, with a Brier score of 0.101 and a non-significant Spiegelhalter z-test (P = 0.319). C-index resulted in 0.827 (95%CI 0.741-0.913).A simple nomogram based on always-available pathologic information accurately predicts the probability of HER2 positivity in GOC." @default.
- W2914419657 created "2019-02-21" @default.
- W2914419657 creator A5007977237 @default.
- W2914419657 creator A5008698979 @default.
- W2914419657 creator A5009272132 @default.
- W2914419657 creator A5017474339 @default.
- W2914419657 creator A5019141029 @default.
- W2914419657 creator A5023227998 @default.
- W2914419657 creator A5026345672 @default.
- W2914419657 creator A5034659601 @default.
- W2914419657 creator A5036615333 @default.
- W2914419657 creator A5047673996 @default.
- W2914419657 creator A5051513508 @default.
- W2914419657 creator A5056137515 @default.
- W2914419657 creator A5065706073 @default.
- W2914419657 creator A5068353710 @default.
- W2914419657 creator A5069129399 @default.
- W2914419657 creator A5072011188 @default.
- W2914419657 creator A5077222725 @default.
- W2914419657 creator A5082066847 @default.
- W2914419657 creator A5090671983 @default.
- W2914419657 creator A5090823817 @default.
- W2914419657 date "2019-02-12" @default.
- W2914419657 modified "2023-10-18" @default.
- W2914419657 title "Validated clinico-pathologic nomogram in the prediction of HER2 status in gastro-oesophageal cancer" @default.
- W2914419657 cites W1176709326 @default.
- W2914419657 cites W1757407923 @default.
- W2914419657 cites W1978688915 @default.
- W2914419657 cites W1987009448 @default.
- W2914419657 cites W1991004886 @default.
- W2914419657 cites W2015918488 @default.
- W2914419657 cites W2017176432 @default.
- W2914419657 cites W2030807319 @default.
- W2914419657 cites W2044513926 @default.
- W2914419657 cites W2062004184 @default.
- W2914419657 cites W2074134583 @default.
- W2914419657 cites W2100439220 @default.
- W2914419657 cites W2114489245 @default.
- W2914419657 cites W2136197678 @default.
- W2914419657 cites W2137990512 @default.
- W2914419657 cites W2155275416 @default.
- W2914419657 cites W2169560977 @default.
- W2914419657 cites W2198367850 @default.
- W2914419657 cites W2334852621 @default.
- W2914419657 cites W2471512801 @default.
- W2914419657 cites W2512765729 @default.
- W2914419657 cites W2556376431 @default.
- W2914419657 cites W2587433409 @default.
- W2914419657 cites W2594180593 @default.
- W2914419657 cites W2609897303 @default.
- W2914419657 cites W2766565770 @default.
- W2914419657 cites W4211007657 @default.
- W2914419657 doi "https://doi.org/10.1038/s41416-019-0399-4" @default.
- W2914419657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6461920" @default.
- W2914419657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30745584" @default.
- W2914419657 hasPublicationYear "2019" @default.
- W2914419657 type Work @default.
- W2914419657 sameAs 2914419657 @default.
- W2914419657 citedByCount "11" @default.
- W2914419657 countsByYear W29144196572020 @default.
- W2914419657 countsByYear W29144196572021 @default.
- W2914419657 countsByYear W29144196572022 @default.
- W2914419657 crossrefType "journal-article" @default.
- W2914419657 hasAuthorship W2914419657A5007977237 @default.
- W2914419657 hasAuthorship W2914419657A5008698979 @default.
- W2914419657 hasAuthorship W2914419657A5009272132 @default.
- W2914419657 hasAuthorship W2914419657A5017474339 @default.
- W2914419657 hasAuthorship W2914419657A5019141029 @default.
- W2914419657 hasAuthorship W2914419657A5023227998 @default.
- W2914419657 hasAuthorship W2914419657A5026345672 @default.
- W2914419657 hasAuthorship W2914419657A5034659601 @default.
- W2914419657 hasAuthorship W2914419657A5036615333 @default.
- W2914419657 hasAuthorship W2914419657A5047673996 @default.
- W2914419657 hasAuthorship W2914419657A5051513508 @default.
- W2914419657 hasAuthorship W2914419657A5056137515 @default.
- W2914419657 hasAuthorship W2914419657A5065706073 @default.
- W2914419657 hasAuthorship W2914419657A5068353710 @default.
- W2914419657 hasAuthorship W2914419657A5069129399 @default.
- W2914419657 hasAuthorship W2914419657A5072011188 @default.
- W2914419657 hasAuthorship W2914419657A5077222725 @default.
- W2914419657 hasAuthorship W2914419657A5082066847 @default.
- W2914419657 hasAuthorship W2914419657A5090671983 @default.
- W2914419657 hasAuthorship W2914419657A5090823817 @default.
- W2914419657 hasBestOaLocation W29144196571 @default.
- W2914419657 hasConcept C105795698 @default.
- W2914419657 hasConcept C121608353 @default.
- W2914419657 hasConcept C126322002 @default.
- W2914419657 hasConcept C142724271 @default.
- W2914419657 hasConcept C143998085 @default.
- W2914419657 hasConcept C146357865 @default.
- W2914419657 hasConcept C151730666 @default.
- W2914419657 hasConcept C151956035 @default.
- W2914419657 hasConcept C154945302 @default.
- W2914419657 hasConcept C161584116 @default.
- W2914419657 hasConcept C18903297 @default.
- W2914419657 hasConcept C2775934546 @default.
- W2914419657 hasConcept C2777286243 @default.
- W2914419657 hasConcept C33923547 @default.