Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914437367> ?p ?o ?g. }
- W2914437367 endingPage "697" @default.
- W2914437367 startingPage "692" @default.
- W2914437367 abstract "Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence and has no guideline-recommended therapy, related in part to a lack of mechanism. Traditionally, HFpEF was thought to be secondary to afterload overload due to systemic hypertension; however, accumulating evidence suggests that HFpEF continues to worsen despite adequate control of blood pressure. Emerging data support the suggestion that myocardial ischemia secondary to coronary microvascular dysfunction could be the new paradigm pathophysiology. Several prospective, observational cohort studies indicate that the outcomes of patients with microvascular dysfunction, after an interval of several years, are dominated by HFpEF hospitalizations. Further, the most prevalent clinical phenotype (eg older women with multiple comorbidities) of patients with HFpEF resembles those with coronary microvascular dysfunction, albeit older. In this review, we provide in-depth insight about this emerging HFpEF paradigm, discuss potential therapeutic implications of this pathophysiology, and summarize some important knowledge gaps." @default.
- W2914437367 created "2019-02-21" @default.
- W2914437367 creator A5025903893 @default.
- W2914437367 creator A5084059173 @default.
- W2914437367 date "2019-06-01" @default.
- W2914437367 modified "2023-09-25" @default.
- W2914437367 title "Heart Failure With Preserved Ejection Fraction: Is Ischemia Due to Coronary Microvascular Dysfunction a Mechanistic Factor?" @default.
- W2914437367 cites W1518273993 @default.
- W2914437367 cites W164205712 @default.
- W2914437367 cites W189141079 @default.
- W2914437367 cites W1970402870 @default.
- W2914437367 cites W1981036651 @default.
- W2914437367 cites W1991438746 @default.
- W2914437367 cites W1996423294 @default.
- W2914437367 cites W2004491509 @default.
- W2914437367 cites W2032093326 @default.
- W2914437367 cites W2032456441 @default.
- W2914437367 cites W2052907407 @default.
- W2914437367 cites W2067292833 @default.
- W2914437367 cites W2068519950 @default.
- W2914437367 cites W2069060200 @default.
- W2914437367 cites W2079379410 @default.
- W2914437367 cites W2085175876 @default.
- W2914437367 cites W2105261767 @default.
- W2914437367 cites W2110123637 @default.
- W2914437367 cites W2116045728 @default.
- W2914437367 cites W2117239217 @default.
- W2914437367 cites W2143018886 @default.
- W2914437367 cites W2143094666 @default.
- W2914437367 cites W2146264128 @default.
- W2914437367 cites W2154945560 @default.
- W2914437367 cites W2160072520 @default.
- W2914437367 cites W2163584170 @default.
- W2914437367 cites W2166504467 @default.
- W2914437367 cites W2170375510 @default.
- W2914437367 cites W2202319864 @default.
- W2914437367 cites W2209002211 @default.
- W2914437367 cites W2213926659 @default.
- W2914437367 cites W2236256783 @default.
- W2914437367 cites W2256871273 @default.
- W2914437367 cites W2340854256 @default.
- W2914437367 cites W2476150747 @default.
- W2914437367 cites W2520992996 @default.
- W2914437367 cites W2556842465 @default.
- W2914437367 cites W2581738455 @default.
- W2914437367 cites W2596803679 @default.
- W2914437367 cites W2601765095 @default.
- W2914437367 cites W2604584410 @default.
- W2914437367 cites W2619929899 @default.
- W2914437367 cites W2626105304 @default.
- W2914437367 cites W2626446274 @default.
- W2914437367 cites W2626537737 @default.
- W2914437367 cites W2649240144 @default.
- W2914437367 cites W2778464949 @default.
- W2914437367 cites W2810493462 @default.
- W2914437367 cites W2898718238 @default.
- W2914437367 doi "https://doi.org/10.1016/j.amjmed.2018.12.038" @default.
- W2914437367 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7722793" @default.
- W2914437367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30684452" @default.
- W2914437367 hasPublicationYear "2019" @default.
- W2914437367 type Work @default.
- W2914437367 sameAs 2914437367 @default.
- W2914437367 citedByCount "37" @default.
- W2914437367 countsByYear W29144373672019 @default.
- W2914437367 countsByYear W29144373672020 @default.
- W2914437367 countsByYear W29144373672021 @default.
- W2914437367 countsByYear W29144373672022 @default.
- W2914437367 countsByYear W29144373672023 @default.
- W2914437367 crossrefType "journal-article" @default.
- W2914437367 hasAuthorship W2914437367A5025903893 @default.
- W2914437367 hasAuthorship W2914437367A5084059173 @default.
- W2914437367 hasBestOaLocation W29144373672 @default.
- W2914437367 hasConcept C10162356 @default.
- W2914437367 hasConcept C123576724 @default.
- W2914437367 hasConcept C126322002 @default.
- W2914437367 hasConcept C164705383 @default.
- W2914437367 hasConcept C177713679 @default.
- W2914437367 hasConcept C2777099384 @default.
- W2914437367 hasConcept C2778198053 @default.
- W2914437367 hasConcept C541997718 @default.
- W2914437367 hasConcept C71924100 @default.
- W2914437367 hasConcept C78085059 @default.
- W2914437367 hasConcept C84393581 @default.
- W2914437367 hasConceptScore W2914437367C10162356 @default.
- W2914437367 hasConceptScore W2914437367C123576724 @default.
- W2914437367 hasConceptScore W2914437367C126322002 @default.
- W2914437367 hasConceptScore W2914437367C164705383 @default.
- W2914437367 hasConceptScore W2914437367C177713679 @default.
- W2914437367 hasConceptScore W2914437367C2777099384 @default.
- W2914437367 hasConceptScore W2914437367C2778198053 @default.
- W2914437367 hasConceptScore W2914437367C541997718 @default.
- W2914437367 hasConceptScore W2914437367C71924100 @default.
- W2914437367 hasConceptScore W2914437367C78085059 @default.
- W2914437367 hasConceptScore W2914437367C84393581 @default.
- W2914437367 hasIssue "6" @default.
- W2914437367 hasLocation W29144373671 @default.
- W2914437367 hasLocation W29144373672 @default.
- W2914437367 hasLocation W29144373673 @default.