FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914441803> ?p ?o ?g. }

• W2914441803 abstract "Heart valves reside in a dynamic mechanical environment experiencing a multitude of forces. These forces have been shown to play a key role in valvular pathophysiology. However, knowledge of proteins involved in valvular mechanobiology is limited to only a few proteins of interest, namely, α-smooth muscle actin, transforming growth factor β, etc. Valvular endothelium mediates valvular homeostasis and controls valvular interstitial cell phenotype transformation. But, how endothelium mediates valvular response to dynamic forces is also unknown. In this study, proteomic analysis of mitral valve anterior leaflets under 10% cyclic radial strain was performed. Endothelium from these samples was removed to test how endothelium mediates mitral valve response to stretch. Results show that stretch downregulated cytoskeletal proteins and proteins involved in energy metabolism such as glycolysis and oxireductase activity. Endothelium removal resulted in downregulation of extracellular matrix and cell-matrix adhesion proteins. Removal of endothelium also resulted in upregulation of translation-related and chaperone proteins. Overall, this high throughput study provides insights into new protein groups that may be involved in mitral valve response to mechanical stretch and loss of endothelium. Impact statement This work is important to the field of heart valve pathophysiology as it provides new insights into molecular markers of mechanically induced valvular degeneration as well as the protective role of the valvular endothelium. These discoveries reported here advance our current knowledge of the valvular endothelium and how its removal essentially takes valve leaflets into an environmental shock. In addition, it shows that static conditions represent a mild pathological state for valve leaflets, while 10% cyclic stretch provides valvular cell quiescence. These findings impact the field by informing disease stages and by providing potential new drug targets to reverse or slow down valvular change before it affects cardiac function." @default.
• W2914441803 created "2019-02-21" @default.
• W2914441803 creator A5032011366 @default.
• W2914441803 creator A5044194212 @default.
• W2914441803 creator A5055306895 @default.
• W2914441803 date "2019-02-05" @default.
• W2914441803 modified "2023-10-16" @default.
• W2914441803 title "The effect of physiological stretch and the valvular endothelium on mitral valve proteomes" @default.
• W2914441803 cites W1516095885 @default.
• W2914441803 cites W1606591506 @default.
• W2914441803 cites W1844301679 @default.
• W2914441803 cites W19217443 @default.
• W2914441803 cites W1932669647 @default.
• W2914441803 cites W1965285580 @default.
• W2914441803 cites W1965917470 @default.
• W2914441803 cites W1967483573 @default.
• W2914441803 cites W1968514620 @default.
• W2914441803 cites W1971108880 @default.
• W2914441803 cites W1973241467 @default.
• W2914441803 cites W1974317063 @default.
• W2914441803 cites W1983604682 @default.
• W2914441803 cites W1990852843 @default.
• W2914441803 cites W1991603875 @default.
• W2914441803 cites W1991642199 @default.
• W2914441803 cites W1992992001 @default.
• W2914441803 cites W1994568523 @default.
• W2914441803 cites W1994846158 @default.
• W2914441803 cites W1996369655 @default.
• W2914441803 cites W2000209404 @default.
• W2914441803 cites W2000294086 @default.
• W2914441803 cites W2000300885 @default.
• W2914441803 cites W2002174535 @default.
• W2914441803 cites W2020654012 @default.
• W2914441803 cites W2022114640 @default.
• W2914441803 cites W2031856001 @default.
• W2914441803 cites W2032535848 @default.
• W2914441803 cites W2038854973 @default.
• W2914441803 cites W2039981498 @default.
• W2914441803 cites W2041204786 @default.
• W2914441803 cites W2043635105 @default.
• W2914441803 cites W2045514661 @default.
• W2914441803 cites W2046445536 @default.
• W2914441803 cites W2048977489 @default.
• W2914441803 cites W2053721676 @default.
• W2914441803 cites W2054394926 @default.
• W2914441803 cites W2055268224 @default.
• W2914441803 cites W2059122391 @default.
• W2914441803 cites W2063512204 @default.
• W2914441803 cites W2063642210 @default.
• W2914441803 cites W2072692855 @default.
• W2914441803 cites W2073982480 @default.
• W2914441803 cites W2074939226 @default.
• W2914441803 cites W2075613568 @default.
• W2914441803 cites W2076790676 @default.
• W2914441803 cites W2081008365 @default.
• W2914441803 cites W2082082688 @default.
• W2914441803 cites W2088080018 @default.
• W2914441803 cites W2091950241 @default.
• W2914441803 cites W2094381386 @default.
• W2914441803 cites W2096173332 @default.
• W2914441803 cites W2103626774 @default.
• W2914441803 cites W2107388688 @default.
• W2914441803 cites W2116592054 @default.
• W2914441803 cites W2116703462 @default.
• W2914441803 cites W2121846875 @default.
• W2914441803 cites W2122588714 @default.
• W2914441803 cites W2129162784 @default.
• W2914441803 cites W2130352196 @default.
• W2914441803 cites W2131202416 @default.
• W2914441803 cites W2137551251 @default.
• W2914441803 cites W2138038401 @default.
• W2914441803 cites W2141023931 @default.
• W2914441803 cites W2141298377 @default.
• W2914441803 cites W2145335014 @default.
• W2914441803 cites W2148927308 @default.
• W2914441803 cites W2164717367 @default.
• W2914441803 cites W2170041748 @default.
• W2914441803 cites W2170326026 @default.
• W2914441803 cites W2170364393 @default.
• W2914441803 cites W2170776626 @default.
• W2914441803 cites W2171108436 @default.
• W2914441803 cites W2300580832 @default.
• W2914441803 cites W2403336368 @default.
• W2914441803 cites W2537623931 @default.
• W2914441803 cites W2559466477 @default.
• W2914441803 cites W2578681878 @default.
• W2914441803 cites W2602623272 @default.
• W2914441803 cites W2751355024 @default.
• W2914441803 cites W2775223530 @default.
• W2914441803 cites W2884149103 @default.
• W2914441803 cites W4210739731 @default.
• W2914441803 doi "https://doi.org/10.1177/1535370219829006" @default.
• W2914441803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425102" @default.
• W2914441803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30722697" @default.
• W2914441803 hasPublicationYear "2019" @default.
• W2914441803 type Work @default.
• W2914441803 sameAs 2914441803 @default.
• W2914441803 citedByCount "3" @default.
• W2914441803 countsByYear W29144418032019 @default.
• W2914441803 countsByYear W29144418032020 @default.

• next