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- W2914446611 abstract "BACKGROUND Tendon is a mechanosensitive tissue which transmits muscle derived forces to bones. Photobiomodulation (PBM) also known as low-level laser (or light) therapy (LLLT), has been used in therapeutic approaches in tendon lesions but uncertainties about its mechanisms of action have prevented its widespread use so far. We investigated the response of LLLT therapy in experimental lesions of the calcaneous tendon in rats. METHODS AND MATERIAL Thirty adult male Wistar rats weighing 250 to 300 g were surgically submitted to bilateral partial transverse section of the calcaneous tendon. The right tendon was treated with LLLT whereas the left tendon served as control. On the third postoperative day, the rats were divided into three experimental groups consisting of ten rats each which were treated with LLLT (Konf, Aculas – HB 750), 780 nm and 80 mW for 20 seconds, three times/week for 7, 14 and 28 days. The Sca-1 was examined by immunohistochemistry and histomorphometry and COLA1, COLA2 and COLA3 gene expression by qRT-PCR. RESULTS COLA2 gene expression was higher in LLLT treated rats as compared to the control group. Interestingly, the histomorphometric analysis coincided with increased number of mesenchymal cells, characterized by Sca-1 expression in the lesion region (p<0.001). CONCLUSION LLLT effectively interferes in tendon tissue repair after injury by stimulating mesenchymal cells proliferation and synthesis of collagen type II, which could provide structural support to the interstitial tissues during the healing process of the calcaneous tendon. Further studies are needed to confirm LLLT role in tendon healing. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W2914446611 created "2019-02-21" @default.
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- W2914446611 date "2018-04-01" @default.
- W2914446611 modified "2023-09-28" @default.
- W2914446611 title "LOW LEVEL LASER THERAPY INCREASES MESENCHYMAL CELL PROLIFERATION AND COLLAGEN II AFTER EXPERIMENTAL INJURY" @default.
- W2914446611 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.645.2" @default.
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