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- W291444668 abstract "This chapter discusses the acute tolerance to and dependence upon opioid peptides in single spinal, striatal, and cortical neurons of rats. The major effect of systemically or microiontophoretically applied opiates and opioid peptides on the most sensitive neurons in the central and peripheral nervous system is a decrease in excitability. There are at least two proposed mechanisms by which these depressant effects could be produced. The first is a presynaptic effect, where the release of excitatory transmitter is decreased by opiates. The second is a postsynaptic effect by which the efficacy of an excitatory neurotransmitter substance is decreased. Recent histochemical investigations that established axo-dendritic and axo-somatic synapses for enkephalin-containing interneurons and their target cells in the dorsal horn of the spinal cord support the view of a postsynaptic site of action and seem to rule out a presynaptic interaction between opioid peptides and for example, primary afferent fibers." @default.
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- W291444668 date "1983-01-01" @default.
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- W291444668 title "Acute Tolerance to and Dependence Upon Opioid Peptides in Single Spinal, Striatal and Cortical Neurons of Rats" @default.
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- W291444668 doi "https://doi.org/10.1016/b978-0-08-029804-7.50035-4" @default.
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