FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914451144> ?p ?o ?g. }

• W2914451144 endingPage "479" @default.
• W2914451144 startingPage "466" @default.
• W2914451144 abstract "Programmed death-1 (PD-1), a key immune checkpoint molecule, has been developed as an oncotherapy target for various carcinomas. However, treatment with anti-PD-1 elicited only a minimal effect in pancreatic ductal adenocarcinoma (PDAC). Subsequent studies revealed the existence of a subset of PD-1+ T cells coexpressing CD38 and CD101, representing a fixed dysfunctional subpopulation that are not able to be rescued by anti-PD-1 immunotherapy. However, whether this subpopulation of PD-1 expressing CD8+ T cells could be useful in predicting PDAC stage or prognosing survival is unknown. In this study, we used flow cytometry and immunofluorescence assay to analyze the expression of CD38 and CD101 in 183 clinical PDAC samples, including 84 of peripheral blood and 99 of surgical tissues. High coexpression of CD38/CD101 on peripheral PD-1+CD8+ T cells or tumor-infiltrating lymphocytes (TILs) was found to be most significantly correlated with Tumor/Node/Metastasis (T/N/M) classification and clinical stage, in contrast PD-1+CD8+ T cells could not correlate with T classification. CD38/CD101 co-repression on TILs also correlated with the poor survival in these PDAC patient samples. Our data suggest that CD38/CD101 might represent a more helpful biomarker than PD-1 alone for diagnosis and prognosis of PDAC." @default.
• W2914451144 created "2019-02-21" @default.
• W2914451144 creator A5000506666 @default.
• W2914451144 creator A5002365671 @default.
• W2914451144 creator A5044544424 @default.
• W2914451144 creator A5051439492 @default.
• W2914451144 creator A5053483219 @default.
• W2914451144 creator A5067593913 @default.
• W2914451144 creator A5070542384 @default.
• W2914451144 creator A5076103004 @default.
• W2914451144 creator A5083634448 @default.
• W2914451144 date "2019-01-28" @default.
• W2914451144 modified "2023-10-16" @default.
• W2914451144 title "Prognostic Values of CD38⁺CD101⁺PD1⁺CD8⁺ T Cells in Pancreatic Cancer" @default.
• W2914451144 cites W1594758815 @default.
• W2914451144 cites W1744273349 @default.
• W2914451144 cites W1966648901 @default.
• W2914451144 cites W1976284083 @default.
• W2914451144 cites W1994993231 @default.
• W2914451144 cites W2015663429 @default.
• W2914451144 cites W2023413904 @default.
• W2914451144 cites W2050458717 @default.
• W2914451144 cites W2054373401 @default.
• W2914451144 cites W2059865220 @default.
• W2914451144 cites W2101387096 @default.
• W2914451144 cites W2110305039 @default.
• W2914451144 cites W2124427232 @default.
• W2914451144 cites W2158055765 @default.
• W2914451144 cites W2160391606 @default.
• W2914451144 cites W2235523093 @default.
• W2914451144 cites W2279794760 @default.
• W2914451144 cites W2313784740 @default.
• W2914451144 cites W2336912866 @default.
• W2914451144 cites W2402433991 @default.
• W2914451144 cites W2406612864 @default.
• W2914451144 cites W2514996992 @default.
• W2914451144 cites W2519085778 @default.
• W2914451144 cites W2578528809 @default.
• W2914451144 cites W2616155686 @default.
• W2914451144 cites W2744161674 @default.
• W2914451144 cites W2744696653 @default.
• W2914451144 cites W2750317630 @default.
• W2914451144 cites W4210976084 @default.
• W2914451144 doi "https://doi.org/10.1080/08820139.2019.1566356" @default.
• W2914451144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30689488" @default.
• W2914451144 hasPublicationYear "2019" @default.
• W2914451144 type Work @default.
• W2914451144 sameAs 2914451144 @default.
• W2914451144 citedByCount "24" @default.
• W2914451144 countsByYear W29144511442019 @default.
• W2914451144 countsByYear W29144511442020 @default.
• W2914451144 countsByYear W29144511442021 @default.
• W2914451144 countsByYear W29144511442022 @default.
• W2914451144 countsByYear W29144511442023 @default.
• W2914451144 crossrefType "journal-article" @default.
• W2914451144 hasAuthorship W2914451144A5000506666 @default.
• W2914451144 hasAuthorship W2914451144A5002365671 @default.
• W2914451144 hasAuthorship W2914451144A5044544424 @default.
• W2914451144 hasAuthorship W2914451144A5051439492 @default.
• W2914451144 hasAuthorship W2914451144A5053483219 @default.
• W2914451144 hasAuthorship W2914451144A5067593913 @default.
• W2914451144 hasAuthorship W2914451144A5070542384 @default.
• W2914451144 hasAuthorship W2914451144A5076103004 @default.
• W2914451144 hasAuthorship W2914451144A5083634448 @default.
• W2914451144 hasBestOaLocation W29144511442 @default.
• W2914451144 hasConcept C10205521 @default.
• W2914451144 hasConcept C121608353 @default.
• W2914451144 hasConcept C126322002 @default.
• W2914451144 hasConcept C159912055 @default.
• W2914451144 hasConcept C167672396 @default.
• W2914451144 hasConcept C203014093 @default.
• W2914451144 hasConcept C2777701055 @default.
• W2914451144 hasConcept C2780210213 @default.
• W2914451144 hasConcept C28328180 @default.
• W2914451144 hasConcept C502942594 @default.
• W2914451144 hasConcept C54355233 @default.
• W2914451144 hasConcept C553184892 @default.
• W2914451144 hasConcept C71924100 @default.
• W2914451144 hasConcept C86803240 @default.
• W2914451144 hasConcept C8891405 @default.
• W2914451144 hasConceptScore W2914451144C10205521 @default.
• W2914451144 hasConceptScore W2914451144C121608353 @default.
• W2914451144 hasConceptScore W2914451144C126322002 @default.
• W2914451144 hasConceptScore W2914451144C159912055 @default.
• W2914451144 hasConceptScore W2914451144C167672396 @default.
• W2914451144 hasConceptScore W2914451144C203014093 @default.
• W2914451144 hasConceptScore W2914451144C2777701055 @default.
• W2914451144 hasConceptScore W2914451144C2780210213 @default.
• W2914451144 hasConceptScore W2914451144C28328180 @default.
• W2914451144 hasConceptScore W2914451144C502942594 @default.
• W2914451144 hasConceptScore W2914451144C54355233 @default.
• W2914451144 hasConceptScore W2914451144C553184892 @default.
• W2914451144 hasConceptScore W2914451144C71924100 @default.
• W2914451144 hasConceptScore W2914451144C86803240 @default.
• W2914451144 hasConceptScore W2914451144C8891405 @default.
• W2914451144 hasFunder F4320321001 @default.
• W2914451144 hasFunder F4320327065 @default.
• W2914451144 hasIssue "5" @default.

• next