Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914459969> ?p ?o ?g. }
- W2914459969 endingPage "181" @default.
- W2914459969 startingPage "171" @default.
- W2914459969 abstract "Abstract In Western countries, a rising incidence of obesity and type 2 diabetes correlates with an increase of non-alcoholic steatohepatitis (NASH)—a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). NASH is associated with chronic liver injury, triggering hepatocyte death and enhanced translocation of intestinal bacteria, leading to persistent liver inflammation through activation of Toll-like receptors and their adapter protein myeloid differentiation factor 88 (MyD88). Therefore, we investigated the role of MyD88 during progression from NASH to HCC using a mouse model of chronic liver injury (hepatocyte-specific deletion of nuclear factor κB essential modulator, Nemo; NemoΔhepa). NemoΔhepa; NemoΔhepa/MyD88−/− and NemoΔhepa/MyD88Δhepa were generated and the impact on liver disease progression was investigated. Ubiquitous MyD88 ablation (NemoΔhepa/MyD88−/−) aggravated the degree of liver damage, accompanied by an overall decrease in inflammation, whereas infiltrating macrophages and natural killer cells were elevated. At a later stage, MyD88 deficiency impaired HCC formation. In contrast, hepatocyte-specific MyD88 deletion (NemoΔhepa/MyD88Δhepa) did not affect disease progression. These results suggest that signaling of Toll-like receptors through MyD88 in non-parenchymal liver cells is required for carcinogenesis during chronic liver injury. Hence, blocking MyD88 signaling may offer a therapeutic option to prevent HCC formation in patients with NASH." @default.
- W2914459969 created "2019-02-21" @default.
- W2914459969 creator A5006242340 @default.
- W2914459969 creator A5010265948 @default.
- W2914459969 creator A5019977975 @default.
- W2914459969 creator A5043622673 @default.
- W2914459969 creator A5044642160 @default.
- W2914459969 creator A5069377644 @default.
- W2914459969 date "2019-02-13" @default.
- W2914459969 modified "2023-09-27" @default.
- W2914459969 title "MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis" @default.
- W2914459969 cites W1563798247 @default.
- W2914459969 cites W1757407923 @default.
- W2914459969 cites W1805542971 @default.
- W2914459969 cites W1966799282 @default.
- W2914459969 cites W1969981758 @default.
- W2914459969 cites W1970853163 @default.
- W2914459969 cites W1989521990 @default.
- W2914459969 cites W1996120614 @default.
- W2914459969 cites W2004256529 @default.
- W2914459969 cites W2006471464 @default.
- W2914459969 cites W2010648922 @default.
- W2914459969 cites W2017742161 @default.
- W2914459969 cites W2021487557 @default.
- W2914459969 cites W2027931900 @default.
- W2914459969 cites W2035320249 @default.
- W2914459969 cites W2039845199 @default.
- W2914459969 cites W2061715282 @default.
- W2914459969 cites W2068037459 @default.
- W2914459969 cites W2070597700 @default.
- W2914459969 cites W2085153086 @default.
- W2914459969 cites W2087863438 @default.
- W2914459969 cites W2092694126 @default.
- W2914459969 cites W2094514571 @default.
- W2914459969 cites W2101225650 @default.
- W2914459969 cites W2106549878 @default.
- W2914459969 cites W2110385952 @default.
- W2914459969 cites W2117692326 @default.
- W2914459969 cites W2132692852 @default.
- W2914459969 cites W2137257146 @default.
- W2914459969 cites W2162533301 @default.
- W2914459969 cites W2164906049 @default.
- W2914459969 cites W2485030690 @default.
- W2914459969 cites W2753074576 @default.
- W2914459969 cites W2774189642 @default.
- W2914459969 cites W2785091318 @default.
- W2914459969 cites W2792376809 @default.
- W2914459969 cites W4211183069 @default.
- W2914459969 cites W4297063097 @default.
- W2914459969 doi "https://doi.org/10.1093/carcin/bgy173" @default.
- W2914459969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770929" @default.
- W2914459969 hasPublicationYear "2019" @default.
- W2914459969 type Work @default.
- W2914459969 sameAs 2914459969 @default.
- W2914459969 citedByCount "9" @default.
- W2914459969 countsByYear W29144599692020 @default.
- W2914459969 countsByYear W29144599692021 @default.
- W2914459969 countsByYear W29144599692022 @default.
- W2914459969 countsByYear W29144599692023 @default.
- W2914459969 crossrefType "journal-article" @default.
- W2914459969 hasAuthorship W2914459969A5006242340 @default.
- W2914459969 hasAuthorship W2914459969A5010265948 @default.
- W2914459969 hasAuthorship W2914459969A5019977975 @default.
- W2914459969 hasAuthorship W2914459969A5043622673 @default.
- W2914459969 hasAuthorship W2914459969A5044642160 @default.
- W2914459969 hasAuthorship W2914459969A5069377644 @default.
- W2914459969 hasBestOaLocation W29144599692 @default.
- W2914459969 hasConcept C121608353 @default.
- W2914459969 hasConcept C126322002 @default.
- W2914459969 hasConcept C142724271 @default.
- W2914459969 hasConcept C202751555 @default.
- W2914459969 hasConcept C203014093 @default.
- W2914459969 hasConcept C2776200302 @default.
- W2914459969 hasConcept C2776231280 @default.
- W2914459969 hasConcept C2776637226 @default.
- W2914459969 hasConcept C2776914184 @default.
- W2914459969 hasConcept C2777075537 @default.
- W2914459969 hasConcept C2777214474 @default.
- W2914459969 hasConcept C2778019345 @default.
- W2914459969 hasConcept C2778772119 @default.
- W2914459969 hasConcept C2779102576 @default.
- W2914459969 hasConcept C2779134260 @default.
- W2914459969 hasConcept C2779478299 @default.
- W2914459969 hasConcept C502942594 @default.
- W2914459969 hasConcept C55493867 @default.
- W2914459969 hasConcept C555283112 @default.
- W2914459969 hasConcept C71924100 @default.
- W2914459969 hasConcept C86803240 @default.
- W2914459969 hasConceptScore W2914459969C121608353 @default.
- W2914459969 hasConceptScore W2914459969C126322002 @default.
- W2914459969 hasConceptScore W2914459969C142724271 @default.
- W2914459969 hasConceptScore W2914459969C202751555 @default.
- W2914459969 hasConceptScore W2914459969C203014093 @default.
- W2914459969 hasConceptScore W2914459969C2776200302 @default.
- W2914459969 hasConceptScore W2914459969C2776231280 @default.
- W2914459969 hasConceptScore W2914459969C2776637226 @default.
- W2914459969 hasConceptScore W2914459969C2776914184 @default.
- W2914459969 hasConceptScore W2914459969C2777075537 @default.