FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914465345> ?p ?o ?g. }

• W2914465345 endingPage "1751" @default.
• W2914465345 startingPage "1738" @default.
• W2914465345 abstract "Pre-frontal limbic circuitry is vulnerable to effects of stress and injury. We examined microstructure of pre-frontal limbic circuitry after traumatic brain injury (TBI) or extracranial injury (EI) and its relation to post-traumatic stress symptoms (PTSS). Participants aged 8 to 15 years who sustained mild to severe TBI (n = 53) or EI (n = 26) in motor vehicle incidents were compared with healthy children (n = 38) in a prospective longitudinal study. At the seven-week follow-up, diffusion tensor imaging was obtained in all groups; injured children completed PTSS ratings using a validated scale. Using probabilistic diffusion tensor tractography, pathways were seeded from bilateral amygdalae and hippocampi to estimate the trajectory of white matter connecting them to each other and to targeted pre-frontal cortical (PFC) regions. Microstructure was estimated using fractional anisotropy (FA) in white matter and mean diffusivity (MD) in gray matter. Pre-frontal limbic microstructure was similar across groups, except for reduced FA in the right hippocampus to orbital PFC pathway in the injured versus healthy group. We examined microstructure of components of pre-frontal limbic circuitry with concurrently obtained PTSS cluster scores in the injured children. Neither microstructure nor PTSS scores differed significantly in the TBI and EI groups. Across PTSS factors, specific symptom clusters were related positively to higher FA and MD. Higher hyperarousal, avoidance, and re-experiencing symptoms were associated with higher FA in amygdala to pre-frontal and hippocampus to amygdala pathways. Higher hippocampal MD had a central role in hyperarousal and emotional numbing symptoms. Age moderated the relation of white and gray matter microstructure with hyperarousal scores. Our findings are consistent with models of traumatic stress that implicate disrupted top-down PFC and hippocampal moderation of overreactive subcortical threat arousal systems. Alterations in limbic pre-frontal circuitry and PTSS place children with either brain or body injuries at elevated risk for both current and future psychological health problems." @default.
• W2914465345 created "2019-02-21" @default.
• W2914465345 creator A5018438067 @default.
• W2914465345 creator A5022188480 @default.
• W2914465345 creator A5022944335 @default.
• W2914465345 creator A5037741346 @default.
• W2914465345 creator A5051389438 @default.
• W2914465345 creator A5056904892 @default.
• W2914465345 creator A5079126887 @default.
• W2914465345 creator A5082949321 @default.
• W2914465345 creator A5090954840 @default.
• W2914465345 date "2019-06-01" @default.
• W2914465345 modified "2023-09-27" @default.
• W2914465345 title "Post-Traumatic Stress Symptoms after Pediatric Injury: Relation to Pre-Frontal Limbic Circuitry" @default.
• W2914465345 cites W106425895 @default.
• W2914465345 cites W1503126161 @default.
• W2914465345 cites W1562730871 @default.
• W2914465345 cites W1603121691 @default.
• W2914465345 cites W1908346021 @default.
• W2914465345 cites W1963803871 @default.
• W2914465345 cites W1965642520 @default.
• W2914465345 cites W1965697904 @default.
• W2914465345 cites W1972560720 @default.
• W2914465345 cites W1981630211 @default.
• W2914465345 cites W1981803691 @default.
• W2914465345 cites W1984453610 @default.
• W2914465345 cites W1985177731 @default.
• W2914465345 cites W1987375729 @default.
• W2914465345 cites W1987605932 @default.
• W2914465345 cites W1989695568 @default.
• W2914465345 cites W1991240857 @default.
• W2914465345 cites W2001362807 @default.
• W2914465345 cites W2006763459 @default.
• W2914465345 cites W2009140566 @default.
• W2914465345 cites W2009776298 @default.
• W2914465345 cites W2011068063 @default.
• W2914465345 cites W2015455914 @default.
• W2914465345 cites W2023953285 @default.
• W2914465345 cites W2028551407 @default.
• W2914465345 cites W2030117475 @default.
• W2914465345 cites W2033692470 @default.
• W2914465345 cites W2035844985 @default.
• W2914465345 cites W2037280172 @default.
• W2914465345 cites W2038568172 @default.
• W2914465345 cites W2039307775 @default.
• W2914465345 cites W2039964460 @default.
• W2914465345 cites W2042715328 @default.
• W2914465345 cites W2052019737 @default.
• W2914465345 cites W2054005566 @default.
• W2914465345 cites W2056208640 @default.
• W2914465345 cites W2056334255 @default.
• W2914465345 cites W2057006490 @default.
• W2914465345 cites W2058744155 @default.
• W2914465345 cites W2071881327 @default.
• W2914465345 cites W2075495388 @default.
• W2914465345 cites W2079235012 @default.
• W2914465345 cites W2080220338 @default.
• W2914465345 cites W2081255222 @default.
• W2914465345 cites W2084764358 @default.
• W2914465345 cites W2086087622 @default.
• W2914465345 cites W2094943913 @default.
• W2914465345 cites W2103036395 @default.
• W2914465345 cites W2108875835 @default.
• W2914465345 cites W2111957604 @default.
• W2914465345 cites W2134181926 @default.
• W2914465345 cites W2140857866 @default.
• W2914465345 cites W2143337872 @default.
• W2914465345 cites W2150639919 @default.
• W2914465345 cites W2151130155 @default.
• W2914465345 cites W2152739686 @default.
• W2914465345 cites W2154041895 @default.
• W2914465345 cites W2157035009 @default.
• W2914465345 cites W2160215963 @default.
• W2914465345 cites W2167993324 @default.
• W2914465345 cites W2206569584 @default.
• W2914465345 cites W2213735845 @default.
• W2914465345 cites W2240591609 @default.
• W2914465345 cites W2265971920 @default.
• W2914465345 cites W2396678243 @default.
• W2914465345 cites W2415900077 @default.
• W2914465345 cites W2468330494 @default.
• W2914465345 cites W2473992532 @default.
• W2914465345 cites W2485316876 @default.
• W2914465345 cites W2521839929 @default.
• W2914465345 cites W2523665179 @default.
• W2914465345 cites W2526513553 @default.
• W2914465345 cites W2532841108 @default.
• W2914465345 cites W2539651215 @default.
• W2914465345 cites W2543407163 @default.
• W2914465345 cites W2555252532 @default.
• W2914465345 cites W2564300191 @default.
• W2914465345 cites W2588596488 @default.
• W2914465345 cites W2600734209 @default.
• W2914465345 cites W2602575167 @default.
• W2914465345 cites W2621986376 @default.
• W2914465345 cites W2747924037 @default.
• W2914465345 cites W2748103684 @default.
• W2914465345 cites W2749796049 @default.

• next