Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914473497> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2914473497 abstract "Objective: To evaluate the antibacterial activity and neuroprotective capacity of the ethanolic and aqueous extracts of Tarenaya spinosa (T. spinosa) as well as to determine and quantify some of its polyphenols by high performance liquid chromatography with diode-array detection (HPLC-DAD). Methods: The bacterial Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. The drugs gentamicin, norfloxacin and imipenem were used to evaluate the modulating or antagonistic capacity of the T. spinosa extracts. The extract was analysed by HPLC-DAD to determine the main phenolic compounds. For the cell viability tests, individual heads of the Nauphoeta cinerea arthropod model were removed, homogenized in Trifluoromethyl ketone and centrifuged afterwards. Subsequently, 20 μL of NaNO2 were added to the biological material, except in the control group, to evaluate the protection capacity of the extracts. The homogenate of the insect heads was incubated for 2 h in tubes containing tetrazolium bromide. Results: HPLC-DAD demonstrated that the ethanolic extract of T. spinosa presented caffeic acid as the major compound. The ethanolic extract also showed neuroprotective effects at concentrations ≥ 10 μg/mL, while aqueous extract was shown to have a protective effect only at the concentration of 100 μg/mL. The aqueous extract demonstrated a clinically relevant antibacterial activity against the Staphylococcus aureus multidrug resistant strain - MDR, with MIC 512 μg/mL. However, when the extracts were associated with gentamicin and imipenem, a synergism was detected against Staphylococcus aureus and Escherichia coli MDR strains. Conclusions: Although it does not present an antibacterial action, the extracts of T. spinosa can be used in the pharmaceutical industries since its extracts show modulating action of drugs. Besides, these natural products have neuroprotective capacity." @default.
- W2914473497 created "2019-02-21" @default.
- W2914473497 creator A5003640530 @default.
- W2914473497 creator A5006631483 @default.
- W2914473497 creator A5022261047 @default.
- W2914473497 creator A5022488438 @default.
- W2914473497 creator A5023340924 @default.
- W2914473497 creator A5023754711 @default.
- W2914473497 creator A5033725785 @default.
- W2914473497 creator A5042262093 @default.
- W2914473497 creator A5053463492 @default.
- W2914473497 creator A5054485146 @default.
- W2914473497 creator A5066070259 @default.
- W2914473497 date "2019-01-01" @default.
- W2914473497 modified "2023-10-06" @default.
- W2914473497 title "Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa (Jacq.) Raf. (Cleomaceae)" @default.
- W2914473497 doi "https://doi.org/10.4103/2221-1691.250264" @default.
- W2914473497 hasPublicationYear "2019" @default.
- W2914473497 type Work @default.
- W2914473497 sameAs 2914473497 @default.
- W2914473497 citedByCount "12" @default.
- W2914473497 countsByYear W29144734972019 @default.
- W2914473497 countsByYear W29144734972020 @default.
- W2914473497 countsByYear W29144734972021 @default.
- W2914473497 countsByYear W29144734972022 @default.
- W2914473497 countsByYear W29144734972023 @default.
- W2914473497 crossrefType "journal-article" @default.
- W2914473497 hasAuthorship W2914473497A5003640530 @default.
- W2914473497 hasAuthorship W2914473497A5006631483 @default.
- W2914473497 hasAuthorship W2914473497A5022261047 @default.
- W2914473497 hasAuthorship W2914473497A5022488438 @default.
- W2914473497 hasAuthorship W2914473497A5023340924 @default.
- W2914473497 hasAuthorship W2914473497A5023754711 @default.
- W2914473497 hasAuthorship W2914473497A5033725785 @default.
- W2914473497 hasAuthorship W2914473497A5042262093 @default.
- W2914473497 hasAuthorship W2914473497A5053463492 @default.
- W2914473497 hasAuthorship W2914473497A5054485146 @default.
- W2914473497 hasAuthorship W2914473497A5066070259 @default.
- W2914473497 hasBestOaLocation W29144734971 @default.
- W2914473497 hasConcept C138885662 @default.
- W2914473497 hasConcept C185592680 @default.
- W2914473497 hasConcept C25498285 @default.
- W2914473497 hasConcept C2778004101 @default.
- W2914473497 hasConcept C2780104969 @default.
- W2914473497 hasConcept C2994120714 @default.
- W2914473497 hasConcept C40231798 @default.
- W2914473497 hasConcept C41895202 @default.
- W2914473497 hasConcept C523546767 @default.
- W2914473497 hasConcept C54355233 @default.
- W2914473497 hasConcept C55493867 @default.
- W2914473497 hasConcept C556039675 @default.
- W2914473497 hasConcept C59822182 @default.
- W2914473497 hasConcept C70899900 @default.
- W2914473497 hasConcept C71924100 @default.
- W2914473497 hasConcept C86803240 @default.
- W2914473497 hasConcept C98274493 @default.
- W2914473497 hasConceptScore W2914473497C138885662 @default.
- W2914473497 hasConceptScore W2914473497C185592680 @default.
- W2914473497 hasConceptScore W2914473497C25498285 @default.
- W2914473497 hasConceptScore W2914473497C2778004101 @default.
- W2914473497 hasConceptScore W2914473497C2780104969 @default.
- W2914473497 hasConceptScore W2914473497C2994120714 @default.
- W2914473497 hasConceptScore W2914473497C40231798 @default.
- W2914473497 hasConceptScore W2914473497C41895202 @default.
- W2914473497 hasConceptScore W2914473497C523546767 @default.
- W2914473497 hasConceptScore W2914473497C54355233 @default.
- W2914473497 hasConceptScore W2914473497C55493867 @default.
- W2914473497 hasConceptScore W2914473497C556039675 @default.
- W2914473497 hasConceptScore W2914473497C59822182 @default.
- W2914473497 hasConceptScore W2914473497C70899900 @default.
- W2914473497 hasConceptScore W2914473497C71924100 @default.
- W2914473497 hasConceptScore W2914473497C86803240 @default.
- W2914473497 hasConceptScore W2914473497C98274493 @default.
- W2914473497 hasLocation W29144734971 @default.
- W2914473497 hasLocation W29144734972 @default.
- W2914473497 hasOpenAccess W2914473497 @default.
- W2914473497 hasPrimaryLocation W29144734971 @default.
- W2914473497 hasRelatedWork W139638154 @default.
- W2914473497 hasRelatedWork W1964659357 @default.
- W2914473497 hasRelatedWork W1972060131 @default.
- W2914473497 hasRelatedWork W2588010162 @default.
- W2914473497 hasRelatedWork W2602420469 @default.
- W2914473497 hasRelatedWork W2748952813 @default.
- W2914473497 hasRelatedWork W2807269452 @default.
- W2914473497 hasRelatedWork W2899084033 @default.
- W2914473497 hasRelatedWork W2914473497 @default.
- W2914473497 hasRelatedWork W4235278562 @default.
- W2914473497 isParatext "false" @default.
- W2914473497 isRetracted "false" @default.
- W2914473497 magId "2914473497" @default.
- W2914473497 workType "article" @default.