Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914485122> ?p ?o ?g. }
- W2914485122 endingPage "44" @default.
- W2914485122 startingPage "31" @default.
- W2914485122 abstract "Lymph node (LN) metastasis is the leading cause of bladder cancer-related mortality. Splicing factors facilitate cancer progression by modulating oncogenic variants, but it is unclear whether and how splicing factors regulate bladder cancer LN metastasis. In this study, Polypyrimidine tract binding protein 1 (PTBP1) expression was found to relate to bladder cancer LN metastasis, and was positively correlated with LN metastasis status, tumor stage, histological grade, and poor patient prognosis. Functional assays demonstrated that PTBP1 promoted bladder cancer cell migration, invasion, and proliferation in vitro, as well as LN metastasis and tumor growth in vivo. Mechanistic investigations revealed that PTBP1 upregulated MEIS2-L variant to promote metastasis and increased expression of PKM2 variant to enhance proliferation by modulating alternative mRNA splicing. Moreover, overexpression of MEIS2-L or PKM2 could rescue the oncogenic abilities of bladder cancer cells and the expression of MMP9 or CCND1 respectively after PTBP1 knockdown. In conclusion, our data demonstrate that PTBP1 induces bladder cancer LN metastasis and proliferation through an alternative splicing mechanism. PTBP1 may serve as a novel prognostic marker and therapeutic target for LN-metastatic bladder cancer." @default.
- W2914485122 created "2019-02-21" @default.
- W2914485122 creator A5003905939 @default.
- W2914485122 creator A5025887775 @default.
- W2914485122 creator A5028291712 @default.
- W2914485122 creator A5028479077 @default.
- W2914485122 creator A5028628268 @default.
- W2914485122 creator A5028779704 @default.
- W2914485122 creator A5033881111 @default.
- W2914485122 creator A5042785211 @default.
- W2914485122 creator A5046454314 @default.
- W2914485122 creator A5046744524 @default.
- W2914485122 creator A5053232483 @default.
- W2914485122 creator A5062284808 @default.
- W2914485122 creator A5065859286 @default.
- W2914485122 creator A5067341225 @default.
- W2914485122 date "2019-05-01" @default.
- W2914485122 modified "2023-10-17" @default.
- W2914485122 title "Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM" @default.
- W2914485122 cites W1589165482 @default.
- W2914485122 cites W1642411512 @default.
- W2914485122 cites W1829491214 @default.
- W2914485122 cites W1883773314 @default.
- W2914485122 cites W1968136484 @default.
- W2914485122 cites W1968252785 @default.
- W2914485122 cites W1981282881 @default.
- W2914485122 cites W1984574291 @default.
- W2914485122 cites W1986077139 @default.
- W2914485122 cites W2002536280 @default.
- W2914485122 cites W2004509913 @default.
- W2914485122 cites W2006593022 @default.
- W2914485122 cites W2013301809 @default.
- W2914485122 cites W2015207840 @default.
- W2914485122 cites W2026452911 @default.
- W2914485122 cites W2033593485 @default.
- W2914485122 cites W2038874091 @default.
- W2914485122 cites W2040519762 @default.
- W2914485122 cites W2040870350 @default.
- W2914485122 cites W2042086006 @default.
- W2914485122 cites W2046024621 @default.
- W2914485122 cites W2048255587 @default.
- W2914485122 cites W2054106515 @default.
- W2914485122 cites W2055583355 @default.
- W2914485122 cites W2056290881 @default.
- W2914485122 cites W2059293195 @default.
- W2914485122 cites W2073398027 @default.
- W2914485122 cites W2094887188 @default.
- W2914485122 cites W2099951161 @default.
- W2914485122 cites W2104096631 @default.
- W2914485122 cites W2104810015 @default.
- W2914485122 cites W2107171098 @default.
- W2914485122 cites W2113525941 @default.
- W2914485122 cites W2117490187 @default.
- W2914485122 cites W2126035366 @default.
- W2914485122 cites W2145920293 @default.
- W2914485122 cites W2149163652 @default.
- W2914485122 cites W2153833484 @default.
- W2914485122 cites W2155407103 @default.
- W2914485122 cites W2157085976 @default.
- W2914485122 cites W2166651826 @default.
- W2914485122 cites W2197459998 @default.
- W2914485122 cites W2346030347 @default.
- W2914485122 cites W2513371636 @default.
- W2914485122 cites W2529020914 @default.
- W2914485122 cites W2547444420 @default.
- W2914485122 cites W2549569442 @default.
- W2914485122 cites W2555357497 @default.
- W2914485122 cites W2588974142 @default.
- W2914485122 cites W2606204310 @default.
- W2914485122 cites W2607129810 @default.
- W2914485122 cites W2610832389 @default.
- W2914485122 cites W2753148287 @default.
- W2914485122 cites W2760214433 @default.
- W2914485122 cites W2762549764 @default.
- W2914485122 cites W2790809328 @default.
- W2914485122 cites W2796413699 @default.
- W2914485122 cites W2797495365 @default.
- W2914485122 cites W2799551816 @default.
- W2914485122 cites W2855985248 @default.
- W2914485122 cites W2883909688 @default.
- W2914485122 cites W2885882002 @default.
- W2914485122 cites W2894653784 @default.
- W2914485122 cites W2897207453 @default.
- W2914485122 cites W2899888410 @default.
- W2914485122 cites W2910458908 @default.
- W2914485122 cites W2917837889 @default.
- W2914485122 cites W4251731689 @default.
- W2914485122 doi "https://doi.org/10.1016/j.canlet.2019.01.041" @default.
- W2914485122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742945" @default.
- W2914485122 hasPublicationYear "2019" @default.
- W2914485122 type Work @default.
- W2914485122 sameAs 2914485122 @default.
- W2914485122 citedByCount "64" @default.
- W2914485122 countsByYear W29144851222019 @default.
- W2914485122 countsByYear W29144851222020 @default.
- W2914485122 countsByYear W29144851222021 @default.
- W2914485122 countsByYear W29144851222022 @default.
- W2914485122 countsByYear W29144851222023 @default.