FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914486077> ?p ?o ?g. }

• W2914486077 abstract "Aging causes considerable morphological changes in the human brain, both in the gray and white matter, in the form of atrophy and neuronal/axonal changes. While there are many studies of aging and early Alzheimer's disease that have focused on GM anatomy, there are fewer studies of WM structure, which is well characterized by Diffusion Tensor Imaging (DTI). We performed a comprehensive analysis of age effects on WM structure in older adults, using the initial DTI scans from 46 individuals (age 60 – 93 years) enrolled in the Baltimore Longitudinal Study of Aging. Maps of fractional anisotropy (FA), mean diffusivity (MD) and the full tensor were analyzed. The analyses consisted of 1) voxel-based analysis of group differences between relatively younger and older subjects (Group 1(mean: 71.7 years) and Group 2 (mean: 82.7 years)), and 2) regression of FA and MD with age (see figure for representative results). Peri-ventricular regions and the genu of the corpus callossum showed pronounced decreases of FA with age, while regions in frontal and temporal lobes and the insula showed significant increases in MD with age. Statistical analysis on the full tensor (that handles age- or pathology-induced change as a non-linear non-uniform process that can be modeled as changes on a manifold) showed widespread group differences, supporting results from the individual scalar maps of anisotropy and diffusivity. Regression analysis on these scalar maps showed an overall increase of diffusivity in the brain with age and a decrease in anisotropy in several major white matter tracts except in regions around the cingulum bundle where it showed an increase. The rate of decrease in anisotropy was much higher than the rate of increase in diffusivity. Age differences in FA and MD could relate to intrinsic fiber alterations, atrophy, decrease in myelin or neural/fiber loss and may be accounted for by differences in myelination or cerebral pruning during maturation. Overall, although the etiology of age differences in FA, MD and the tensors is not completely known, the study provides a firm foundation for a comprehensive DTI-based longitudinal study to identify potential complementary markers of aging." @default.
• W2914486077 created "2019-02-21" @default.
• W2914486077 creator A5003112344 @default.
• W2914486077 creator A5004020699 @default.
• W2914486077 creator A5029248993 @default.
• W2914486077 creator A5034999945 @default.
• W2914486077 creator A5048196698 @default.
• W2914486077 creator A5049709428 @default.
• W2914486077 creator A5065513121 @default.
• W2914486077 creator A5083518354 @default.
• W2914486077 date "2008-07-01" @default.
• W2914486077 modified "2023-09-27" @default.
• W2914486077 title "P1-305: A diffusion tensor imaging study of markers of white matter aging" @default.
• W2914486077 doi "https://doi.org/10.1016/j.jalz.2008.05.896" @default.
• W2914486077 hasPublicationYear "2008" @default.
• W2914486077 type Work @default.
• W2914486077 sameAs 2914486077 @default.
• W2914486077 citedByCount "0" @default.
• W2914486077 crossrefType "journal-article" @default.
• W2914486077 hasAuthorship W2914486077A5003112344 @default.
• W2914486077 hasAuthorship W2914486077A5004020699 @default.
• W2914486077 hasAuthorship W2914486077A5029248993 @default.
• W2914486077 hasAuthorship W2914486077A5034999945 @default.
• W2914486077 hasAuthorship W2914486077A5048196698 @default.
• W2914486077 hasAuthorship W2914486077A5049709428 @default.
• W2914486077 hasAuthorship W2914486077A5065513121 @default.
• W2914486077 hasAuthorship W2914486077A5083518354 @default.
• W2914486077 hasConcept C121332964 @default.
• W2914486077 hasConcept C126322002 @default.
• W2914486077 hasConcept C126838900 @default.
• W2914486077 hasConcept C143409427 @default.
• W2914486077 hasConcept C149550507 @default.
• W2914486077 hasConcept C15744967 @default.
• W2914486077 hasConcept C169760540 @default.
• W2914486077 hasConcept C2781172350 @default.
• W2914486077 hasConcept C2781192897 @default.
• W2914486077 hasConcept C46141821 @default.
• W2914486077 hasConcept C71924100 @default.
• W2914486077 hasConcept C89916169 @default.
• W2914486077 hasConceptScore W2914486077C121332964 @default.
• W2914486077 hasConceptScore W2914486077C126322002 @default.
• W2914486077 hasConceptScore W2914486077C126838900 @default.
• W2914486077 hasConceptScore W2914486077C143409427 @default.
• W2914486077 hasConceptScore W2914486077C149550507 @default.
• W2914486077 hasConceptScore W2914486077C15744967 @default.
• W2914486077 hasConceptScore W2914486077C169760540 @default.
• W2914486077 hasConceptScore W2914486077C2781172350 @default.
• W2914486077 hasConceptScore W2914486077C2781192897 @default.
• W2914486077 hasConceptScore W2914486077C46141821 @default.
• W2914486077 hasConceptScore W2914486077C71924100 @default.
• W2914486077 hasConceptScore W2914486077C89916169 @default.
• W2914486077 hasIssue "4S_Part_9" @default.
• W2914486077 hasLocation W29144860771 @default.
• W2914486077 hasOpenAccess W2914486077 @default.
• W2914486077 hasPrimaryLocation W29144860771 @default.
• W2914486077 hasRelatedWork W1972609121 @default.
• W2914486077 hasRelatedWork W1980361915 @default.
• W2914486077 hasRelatedWork W2013878049 @default.
• W2914486077 hasRelatedWork W2095446662 @default.
• W2914486077 hasRelatedWork W2102149729 @default.
• W2914486077 hasRelatedWork W2105528651 @default.
• W2914486077 hasRelatedWork W2141510919 @default.
• W2914486077 hasRelatedWork W2170410512 @default.
• W2914486077 hasRelatedWork W2801987413 @default.
• W2914486077 hasRelatedWork W4385979447 @default.
• W2914486077 hasVolume "4" @default.
• W2914486077 isParatext "false" @default.
• W2914486077 isRetracted "false" @default.
• W2914486077 magId "2914486077" @default.
• W2914486077 workType "article" @default.