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- W2914486471 endingPage "1048" @default.
- W2914486471 startingPage "1037" @default.
- W2914486471 abstract "This chapter provides an overview of macrophage migration inhibitory factor (MIF), which is a critical pro-inflammatory mediator that has been found to play an important role in diverse conditions characterized both by inflammation and cellular proliferation. MIF has a number of unique structural, genetic, and functional properties that distinguish it from other cytokines. These properties include unique tertiary structure, catalytic activity, a non-conventional secretory pathway, widespread expression and secretion from endocrine as well as immune cells, and its action as an endogenous counter-regulator of the anti-inflammatory and immunosuppressive properties of steroids. Also, MIF is unique in being a “pro-inflammatory” mediator that is induced in cells by glucocorticoids. Consistent with the wide range of activities of MIF, it has been found to be involved in the pathogenesis of many conditions. Important areas of future investigation includes in identifying the nature, and regulation of the MIF receptor, understanding the regulation of MIF at the genetic level, and designing clinically effective means of inhibiting its activity." @default.
- W2914486471 created "2019-02-21" @default.
- W2914486471 creator A5000651180 @default.
- W2914486471 creator A5029456441 @default.
- W2914486471 date "2003-01-01" @default.
- W2914486471 modified "2023-09-26" @default.
- W2914486471 title "Macrophage migration inhibitory factor (MIF)" @default.
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