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- W2914539439 abstract "Since its discovery ∼30 years ago, our knowledge about membrane cofactor protein (MCP; CD46) has expanded beyond its role as a potent complement regulator that is expressed as a family of four isoforms on most cells and that differ in O-glycosylation and cytoplasmic tails. Initially known as a cofactor for the factor-I-mediated cleavage of C3b and C4b, CD46 functions now include roles as a pathogen magnet, key constituent in human T cell biology, promoter of epithelial cell autophagy and player in reproductive biology. CD46 also is a promising new therapeutic target for xenotransplantation of transgenic CD46-expressing pig organs, for delivery of anti-tumour agents via viruses (especially adenovirus), and for cancer treatment regimens via use of CD46 monoclonal antibodies. Further, since mice primarily express CD46 on spermatozoa and in eye, the Cd46−/− mice may assist CD46 reproductive studies and provide a much needed model to study age-related macular degeneration." @default.
- W2914539439 created "2019-02-21" @default.
- W2914539439 creator A5008491017 @default.
- W2914539439 creator A5084158740 @default.
- W2914539439 date "2018-01-01" @default.
- W2914539439 modified "2023-09-25" @default.
- W2914539439 title "Membrane Cofactor Protein" @default.
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- W2914539439 doi "https://doi.org/10.1016/b978-0-12-810420-0.00026-2" @default.
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