FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914565910> ?p ?o ?g. }

• W2914565910 endingPage "93" @default.
• W2914565910 startingPage "93" @default.
• W2914565910 abstract "Chromatin structure and its organization contributes to the proper regulation and timing of DNA replication. Yet, the precise mechanism by which chromatin contributes to DNA replication remains incompletely understood. This is particularly true for cell types that rely on polyploidization as a developmental strategy for growth and high biosynthetic capacity. During Drosophila larval development, cells of the salivary gland undergo endoreplication, repetitive rounds of DNA synthesis without intervening cell division, resulting in ploidy values of ~1350C. S phase of these endocycles displays a reproducible pattern of early and late replicating regions of the genome resulting from the activity of the same replication initiation factors that are used in diploid cells. However, unlike diploid cells, the latest replicating regions of polyploid salivary gland genomes, composed primarily of pericentric heterochromatic enriched in H3K9 methylation, are not replicated each endocycle, resulting in under-replicated domains with reduced ploidy. Here, we employ a histone gene replacement strategy in Drosophila to demonstrate that mutation of a histone residue important for heterochromatin organization and function (H3K9) but not mutation of a histone residue important for euchromatin function (H4K16), disrupts proper endoreplication in Drosophila salivary gland polyploid genomes thereby leading to DNA copy gain in pericentric heterochromatin. These findings reveal that H3K9 is necessary for normal levels of under-replication of pericentric heterochromatin and suggest that under-replication at pericentric heterochromatin is mediated through H3K9 methylation." @default.
• W2914565910 created "2019-02-21" @default.
• W2914565910 creator A5002078834 @default.
• W2914565910 creator A5003630381 @default.
• W2914565910 creator A5009211981 @default.
• W2914565910 creator A5030342290 @default.
• W2914565910 creator A5043728965 @default.
• W2914565910 creator A5047321571 @default.
• W2914565910 creator A5056814272 @default.
• W2914565910 creator A5069472220 @default.
• W2914565910 date "2019-01-29" @default.
• W2914565910 modified "2023-10-15" @default.
• W2914565910 title "H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes" @default.
• W2914565910 cites W1963938571 @default.
• W2914565910 cites W1964792512 @default.
• W2914565910 cites W1966435085 @default.
• W2914565910 cites W1975692560 @default.
• W2914565910 cites W1989324954 @default.
• W2914565910 cites W1996533937 @default.
• W2914565910 cites W1997581925 @default.
• W2914565910 cites W2011404781 @default.
• W2914565910 cites W2016172184 @default.
• W2914565910 cites W2017237874 @default.
• W2914565910 cites W2030188284 @default.
• W2914565910 cites W2037589637 @default.
• W2914565910 cites W2045171767 @default.
• W2914565910 cites W2046965780 @default.
• W2914565910 cites W2057185906 @default.
• W2914565910 cites W2062968281 @default.
• W2914565910 cites W2077005295 @default.
• W2914565910 cites W2089950231 @default.
• W2914565910 cites W2094964240 @default.
• W2914565910 cites W2095785217 @default.
• W2914565910 cites W2095831178 @default.
• W2914565910 cites W2102619694 @default.
• W2914565910 cites W2110742690 @default.
• W2914565910 cites W2115103304 @default.
• W2914565910 cites W2116015677 @default.
• W2914565910 cites W2119626690 @default.
• W2914565910 cites W2121846200 @default.
• W2914565910 cites W2125030972 @default.
• W2914565910 cites W2129873583 @default.
• W2914565910 cites W2140516843 @default.
• W2914565910 cites W2142410516 @default.
• W2914565910 cites W2142534168 @default.
• W2914565910 cites W2144454035 @default.
• W2914565910 cites W2148076560 @default.
• W2914565910 cites W2150506261 @default.
• W2914565910 cites W2151836800 @default.
• W2914565910 cites W2159342107 @default.
• W2914565910 cites W2160838716 @default.
• W2914565910 cites W2161737516 @default.
• W2914565910 cites W2480728253 @default.
• W2914565910 cites W2509429928 @default.
• W2914565910 cites W2517008357 @default.
• W2914565910 cites W2573192272 @default.
• W2914565910 cites W2606759715 @default.
• W2914565910 cites W2694038906 @default.
• W2914565910 cites W2722642526 @default.
• W2914565910 cites W2751780022 @default.
• W2914565910 cites W2751974672 @default.
• W2914565910 cites W2802855755 @default.
• W2914565910 cites W2887036946 @default.
• W2914565910 cites W2888591155 @default.
• W2914565910 cites W2895188054 @default.
• W2914565910 cites W2901829291 @default.
• W2914565910 cites W2903896515 @default.
• W2914565910 cites W2950898487 @default.
• W2914565910 cites W2952641424 @default.
• W2914565910 cites W4236259349 @default.
• W2914565910 doi "https://doi.org/10.3390/genes10020093" @default.
• W2914565910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6409945" @default.
• W2914565910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30700014" @default.
• W2914565910 hasPublicationYear "2019" @default.
• W2914565910 type Work @default.
• W2914565910 sameAs 2914565910 @default.
• W2914565910 citedByCount "11" @default.
• W2914565910 countsByYear W29145659102018 @default.
• W2914565910 countsByYear W29145659102019 @default.
• W2914565910 countsByYear W29145659102020 @default.
• W2914565910 countsByYear W29145659102021 @default.
• W2914565910 countsByYear W29145659102022 @default.
• W2914565910 crossrefType "journal-article" @default.
• W2914565910 hasAuthorship W2914565910A5002078834 @default.
• W2914565910 hasAuthorship W2914565910A5003630381 @default.
• W2914565910 hasAuthorship W2914565910A5009211981 @default.
• W2914565910 hasAuthorship W2914565910A5030342290 @default.
• W2914565910 hasAuthorship W2914565910A5043728965 @default.
• W2914565910 hasAuthorship W2914565910A5047321571 @default.
• W2914565910 hasAuthorship W2914565910A5056814272 @default.
• W2914565910 hasAuthorship W2914565910A5069472220 @default.
• W2914565910 hasBestOaLocation W29145659101 @default.
• W2914565910 hasConcept C100924687 @default.
• W2914565910 hasConcept C103435993 @default.
• W2914565910 hasConcept C104317684 @default.
• W2914565910 hasConcept C143191323 @default.
• W2914565910 hasConcept C145226528 @default.
• W2914565910 hasConcept C2778512757 @default.

• next