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- W2914567612 abstract "The worldwide use of antibiotics results in the development of bacterial resistance, which poses a threat to the healthcare. With the dearth in the discovery and development of new antibiotics and rapid emergence of multidrug resistant (MDR) Gram-negative bacteria, the optimisation of clinically available antibiotics is highly warranted. For this critical situation, polymyxins, an “old-antibiotic” have been re-birthed as the last therapeutic option for the treatment of the serious bacterial infections. The administration of polymyxins as a single therapy is unlikely to achieve optimal and safe plasma concentration particularly with highly resistant pathogens. To overcome these limitations with polymyxins therapy, a combination with other antibiotics is an option. Better understanding the mode of actions of polymyxin combination therapy is crucially important to achieve maximum benefit." @default.
- W2914567612 created "2019-02-21" @default.
- W2914567612 creator A5074822354 @default.
- W2914567612 date "2019-03-05" @default.
- W2914567612 modified "2023-09-23" @default.
- W2914567612 title "Investigation of the effects of polymymyxins on sub-proteome and lipidome of K. pneumonia" @default.
- W2914567612 doi "https://doi.org/10.26180/5c577f9c10aaa" @default.
- W2914567612 hasPublicationYear "2019" @default.
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