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W2914574719 abstract "The discovery, structure-activity relationships, and optimization of a novel class of fatty acid synthase (FASN) inhibitors is reported. High throughput screening identified a series of substituted piperazines with structural features that enable interactions with many of the potency-driving regions of the FASN KR domain binding site. Derived from this series was FT113, a compound with potent biochemical and cellular activity, which translated into excellent activity in in vivo models." @default.
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W2914574719 date "2019-04-01" @default.
W2914574719 modified "2023-10-12" @default.
W2914574719 title "Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)" @default.
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W2914574719 doi "https://doi.org/10.1016/j.bmcl.2019.02.012" @default.
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