FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914578084> ?p ?o ?g. }

• W2914578084 abstract "The biogenesis of the photosynthetic apparatus in developing chloroplasts requires the assembly of proteins encoded on both nuclear and chloroplast genomes 1 . To co-ordinate this process there needs to be communication between these organelles, and while we have a good understanding of how the nucleus controls chloroplast development, how the chloroplast communicates with the nucleus at this time is still essentially unknown 2 . What we do know comes from pioneering work in which a series of genomes uncoupled ( gun ) mutants were identified that show elevated nuclear gene expression after chloroplast damage 3 . Of the six reported gun mutations, five are in tetrapyrrole biosynthesis proteins 4-6 and this has led to the development of a model for chloroplast-to-nucleus retrograde signaling in which ferrochelatase 1 (FC1)-dependent heme synthesis generates a positive signal promoting expression of photosynthesis-related genes 6 . However, the molecular consequences of the strongest of the gun mutants, gun1 7 , is unknown, preventing the development of a unifying hypothesis for chloroplast-to-nucleus signaling. Here, we show that GUN1 directly binds to heme and other metal-porphyrins, affects flux through the tetrapyrrole biosynthesis pathway and can increase the chelatase activity of FC1. These results raise the possibility that the signaling role of GUN1 may be manifested through changes in tetrapyrrole metabolism and supports a role for tetrapyrroles as mediators of a single biogenic chloroplast-to-nucleus retrograde signaling pathway." @default.
• W2914578084 created "2019-02-21" @default.
• W2914578084 creator A5002295340 @default.
• W2914578084 creator A5010146806 @default.
• W2914578084 creator A5011393427 @default.
• W2914578084 creator A5022740787 @default.
• W2914578084 creator A5036204507 @default.
• W2914578084 creator A5037204583 @default.
• W2914578084 creator A5038884000 @default.
• W2914578084 creator A5053933218 @default.
• W2914578084 creator A5060439850 @default.
• W2914578084 creator A5069515703 @default.
• W2914578084 creator A5074609243 @default.
• W2914578084 creator A5075771147 @default.
• W2914578084 creator A5087762478 @default.
• W2914578084 date "2019-01-28" @default.
• W2914578084 modified "2023-10-16" @default.
• W2914578084 title "GUN1 regulates tetrapyrrole biosynthesis" @default.
• W2914578084 cites W1507573241 @default.
• W2914578084 cites W1958817477 @default.
• W2914578084 cites W1971968092 @default.
• W2914578084 cites W1976804920 @default.
• W2914578084 cites W1980400357 @default.
• W2914578084 cites W1991022711 @default.
• W2914578084 cites W1993989699 @default.
• W2914578084 cites W2007081671 @default.
• W2914578084 cites W2009798288 @default.
• W2914578084 cites W2010027000 @default.
• W2914578084 cites W2029081524 @default.
• W2914578084 cites W2029330897 @default.
• W2914578084 cites W2034636049 @default.
• W2914578084 cites W2041657540 @default.
• W2914578084 cites W2059031901 @default.
• W2914578084 cites W2078290510 @default.
• W2914578084 cites W2086540936 @default.
• W2914578084 cites W2089390718 @default.
• W2914578084 cites W2119697258 @default.
• W2914578084 cites W2135969448 @default.
• W2914578084 cites W2151041036 @default.
• W2914578084 cites W2151103054 @default.
• W2914578084 cites W2160974015 @default.
• W2914578084 cites W2171944258 @default.
• W2914578084 cites W2292699605 @default.
• W2914578084 cites W2510099390 @default.
• W2914578084 cites W2523195106 @default.
• W2914578084 cites W2530407305 @default.
• W2914578084 cites W2594147247 @default.
• W2914578084 cites W2759264279 @default.
• W2914578084 cites W2785075499 @default.
• W2914578084 cites W2899013154 @default.
• W2914578084 cites W4214911971 @default.
• W2914578084 doi "https://doi.org/10.1101/532036" @default.
• W2914578084 hasPublicationYear "2019" @default.
• W2914578084 type Work @default.
• W2914578084 sameAs 2914578084 @default.
• W2914578084 citedByCount "2" @default.
• W2914578084 countsByYear W29145780842019 @default.
• W2914578084 countsByYear W29145780842020 @default.
• W2914578084 crossrefType "posted-content" @default.
• W2914578084 hasAuthorship W2914578084A5002295340 @default.
• W2914578084 hasAuthorship W2914578084A5010146806 @default.
• W2914578084 hasAuthorship W2914578084A5011393427 @default.
• W2914578084 hasAuthorship W2914578084A5022740787 @default.
• W2914578084 hasAuthorship W2914578084A5036204507 @default.
• W2914578084 hasAuthorship W2914578084A5037204583 @default.
• W2914578084 hasAuthorship W2914578084A5038884000 @default.
• W2914578084 hasAuthorship W2914578084A5053933218 @default.
• W2914578084 hasAuthorship W2914578084A5060439850 @default.
• W2914578084 hasAuthorship W2914578084A5069515703 @default.
• W2914578084 hasAuthorship W2914578084A5074609243 @default.
• W2914578084 hasAuthorship W2914578084A5075771147 @default.
• W2914578084 hasAuthorship W2914578084A5087762478 @default.
• W2914578084 hasBestOaLocation W29145780841 @default.
• W2914578084 hasConcept C104317684 @default.
• W2914578084 hasConcept C131934819 @default.
• W2914578084 hasConcept C141231307 @default.
• W2914578084 hasConcept C143065580 @default.
• W2914578084 hasConcept C168240541 @default.
• W2914578084 hasConcept C181199279 @default.
• W2914578084 hasConcept C185592680 @default.
• W2914578084 hasConcept C194082555 @default.
• W2914578084 hasConcept C20750100 @default.
• W2914578084 hasConcept C2776217839 @default.
• W2914578084 hasConcept C2777710969 @default.
• W2914578084 hasConcept C2779520027 @default.
• W2914578084 hasConcept C2780723820 @default.
• W2914578084 hasConcept C2781149050 @default.
• W2914578084 hasConcept C55493867 @default.
• W2914578084 hasConcept C62478195 @default.
• W2914578084 hasConcept C69305403 @default.
• W2914578084 hasConcept C86803240 @default.
• W2914578084 hasConcept C95444343 @default.
• W2914578084 hasConceptScore W2914578084C104317684 @default.
• W2914578084 hasConceptScore W2914578084C131934819 @default.
• W2914578084 hasConceptScore W2914578084C141231307 @default.
• W2914578084 hasConceptScore W2914578084C143065580 @default.
• W2914578084 hasConceptScore W2914578084C168240541 @default.
• W2914578084 hasConceptScore W2914578084C181199279 @default.
• W2914578084 hasConceptScore W2914578084C185592680 @default.
• W2914578084 hasConceptScore W2914578084C194082555 @default.

• next