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- W2914580104 endingPage "190" @default.
- W2914580104 startingPage "167" @default.
- W2914580104 abstract "Epigenetics has emerged as a rapidly growing field for studying the heritable alterations involved in the regulation of gene expression patterns that are not due to changes in DNA sequence. To which, the epigenetic mechanisms, such as DNA methylation and histone modifications, can modulate chromatin structure and gene regulation, during cellular development and differentiation in higher organisms. Recent advancements in high-throughput epigenetic profiling technologies, including bisulfite microarray, bisulfite sequencing, affinity enrichment, ChIP-on-chip, and ChIP sequencing, have generated vast amounts of epigenomic data. In turn, the developments of bioinformatics databases and software tools have thus contributed significantly to the substantial, and growing, interest in epigenetic research. This chapter reviews the key aspects and techniques of computational epigenetics. In particular, the major computational tools, databases, and strategies for epigenetics analysis of DNA methylation and histone modifications have been summarized." @default.
- W2914580104 created "2019-02-21" @default.
- W2914580104 creator A5010577995 @default.
- W2914580104 creator A5076169595 @default.
- W2914580104 date "2017-01-01" @default.
- W2914580104 modified "2023-10-16" @default.
- W2914580104 title "Computational Epigenetics" @default.
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