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• W2914586489 abstract "Antenatal glucocorticoid therapy accelerates fetal lung maturation and treatment of the preterm infant with glucocorticoids reduces the incidence of chronic lung disease and the baby’s dependence on assisted ventilation. Therefore, perinatal glucocorticoid therapy has led to a significant reduction in morbidity and mortality of preterm infants. Despite established beneficial effects, there is increasing evidence that exposure of the offspring to synthetic glucocorticoids during the perinatal period induces long term detrimental effects on growth, the brain, and cardiovascular system. Glucocorticoid therapy in the perinatal period is here to stay. However, current therapy needs refining to maintain benefits but also limit detrimental effects. Detrimental effects of glucocorticoid therapy are partly mediated by increased oxidative stress. We propose combined antioxidant and glucocorticoid therapy may be the safer for the treatment of preterm birth. Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth. Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth. during pregnancy, the period prior to birth. aortic distensibility and aortic pulse wave velocity are two parameters closely related to the elastic function of the aorta and the ability of this vessel to distend. The parameters serve as pathogenic markers in cardiovascular disease. maturational change in which heart cells switch from a single nucleus to two nuclei per cell, which is a terminal differentiation event as cells no longer proliferate after undergoing this change. reduced heart rate in response to a physiological stressor. fractional excretion of sodium ions by the kidney. Refers to the % of Na+ that passes through the kidney, that is eventually excreted in the urine. a newborn child or mammal. relating to the period shortly before and after birth. resistance to blood flow in the peripheral circulation, which consist of responsive vessels that may rapidly alter their state from constriction to dilatation or vice-versa to modulate local blood flow. Key examples of peripheral circulations that contribute to peripheral vascular resistance are the mesenteric and femoral vascular beds. the period after birth, the immediate postnatal period refers to the first 6 weeks following birth. referring to the uterus and placenta as a functional unit." @default.
• W2914586489 created "2019-02-21" @default.
• W2914586489 creator A5065050579 @default.
• W2914586489 creator A5085581640 @default.
• W2914586489 date "2019-04-01" @default.
• W2914586489 modified "2023-09-27" @default.
• W2914586489 title "Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth" @default.
• W2914586489 cites W1546334556 @default.
• W2914586489 cites W1605582164 @default.
• W2914586489 cites W1736650634 @default.
• W2914586489 cites W1875915783 @default.
• W2914586489 cites W1902039366 @default.
• W2914586489 cites W1905851972 @default.
• W2914586489 cites W1965288097 @default.
• W2914586489 cites W1967031602 @default.
• W2914586489 cites W1967140494 @default.
• W2914586489 cites W1967811466 @default.
• W2914586489 cites W1967990214 @default.
• W2914586489 cites W1976097188 @default.
• W2914586489 cites W1976372065 @default.
• W2914586489 cites W1976599392 @default.
• W2914586489 cites W1980816520 @default.
• W2914586489 cites W1983339463 @default.
• W2914586489 cites W1985880447 @default.
• W2914586489 cites W1993958117 @default.
• W2914586489 cites W1998136841 @default.
• W2914586489 cites W2001688984 @default.
• W2914586489 cites W2003741984 @default.
• W2914586489 cites W2005862392 @default.
• W2914586489 cites W2007220487 @default.
• W2914586489 cites W2009968854 @default.
• W2914586489 cites W2013345005 @default.
• W2914586489 cites W2014273178 @default.
• W2914586489 cites W2014668126 @default.
• W2914586489 cites W2015700271 @default.
• W2914586489 cites W2016609773 @default.
• W2914586489 cites W2020548823 @default.
• W2914586489 cites W2020651859 @default.
• W2914586489 cites W2021061086 @default.
• W2914586489 cites W2021951475 @default.
• W2914586489 cites W2025799133 @default.
• W2914586489 cites W2026933710 @default.
• W2914586489 cites W2035489261 @default.
• W2914586489 cites W2039201102 @default.
• W2914586489 cites W2043825000 @default.
• W2914586489 cites W2045767862 @default.
• W2914586489 cites W2046755755 @default.
• W2914586489 cites W2055899762 @default.
• W2914586489 cites W2056579555 @default.
• W2914586489 cites W2065900124 @default.
• W2914586489 cites W2066069844 @default.
• W2914586489 cites W2069080293 @default.
• W2914586489 cites W2071442115 @default.
• W2914586489 cites W2071753395 @default.
• W2914586489 cites W2075560787 @default.
• W2914586489 cites W2076030814 @default.
• W2914586489 cites W2078693874 @default.
• W2914586489 cites W2081140370 @default.
• W2914586489 cites W2082745243 @default.
• W2914586489 cites W2086152607 @default.
• W2914586489 cites W2090002569 @default.
• W2914586489 cites W2092253065 @default.
• W2914586489 cites W2093442618 @default.
• W2914586489 cites W2095425322 @default.
• W2914586489 cites W2096977033 @default.
• W2914586489 cites W2105632027 @default.
• W2914586489 cites W2110650665 @default.
• W2914586489 cites W2111487559 @default.
• W2914586489 cites W2114256210 @default.
• W2914586489 cites W2116416528 @default.
• W2914586489 cites W2119883401 @default.
• W2914586489 cites W2122848273 @default.
• W2914586489 cites W2129127301 @default.
• W2914586489 cites W2135237219 @default.
• W2914586489 cites W2141258338 @default.
• W2914586489 cites W2145134151 @default.
• W2914586489 cites W2154169454 @default.
• W2914586489 cites W2154788623 @default.
• W2914586489 cites W2159995361 @default.
• W2914586489 cites W2160835063 @default.
• W2914586489 cites W2161767734 @default.
• W2914586489 cites W2162531869 @default.
• W2914586489 cites W2169610111 @default.
• W2914586489 cites W2170279236 @default.
• W2914586489 cites W2188028366 @default.
• W2914586489 cites W2324910294 @default.
• W2914586489 cites W2397417653 @default.
• W2914586489 cites W2470954218 @default.
• W2914586489 cites W2799412382 @default.
• W2914586489 cites W2799487021 @default.
• W2914586489 cites W2896962462 @default.
• W2914586489 cites W4237379122 @default.
• W2914586489 doi "https://doi.org/10.1016/j.tem.2019.02.003" @default.
• W2914586489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30850263" @default.
• W2914586489 hasPublicationYear "2019" @default.
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